Publications

15.06.25

The dawn of a new era: can machine learning and large language models reshape QSP modeling?

AutomationJournalMethodologyQSP

J Pharmacokinet Pharmacodyn. 2025 Jun 16;52(4):36.

Androulakis IP, Cucurull-Sanchez L, Kondic A, Mehta K, Pichardo C, , Pryor M, Renardy M.

03.06.25

Physiologically based predictions of monoclonal antibody pharmacokinetics: insights from a large-scale data analysis

ConferencePBPK/PBBMProgram strategies and efficienciesSpecial considerations

PAGE 33 (2025) Abstr 11791

Benamara S, Sjogren E, Gattacceca F, Chenel M, Deslandes A, Nguyen L, Teutonico D.

03.06.25

Development of efficient CAR-T cell clinical study designs: Towards understanding of novel anticancer therapies through optimal experimental design

ConferenceMethodologyOncologyPharmacometricsTrial design and analysis

PAGE 33 (2025) Abstr 11783

Klima F, Mc Laughlin AM, Michelet R, Winkler A, Huisinga W, Haussmann K, Künkele A, Hooker AC, Kloft C..

03.06.25

Application of model-informed drug development for dose optimization of brigimadlin in patients with dedifferentiated liposarcoma

ConferenceMIDDOncologyPharmacometricsPhase IPhase IIPhase IIIProgram strategies and efficienciesTrial design and analysis

PAGE 33 (2025) Abstr 11666

Aguiar Zdovc J, Gausi K, Langenhorst J, Yin A, Acharya C, Sarr C, Friberg LE, Lahmar M, Grempler R, Pérez-Pitarch A, Schmid U, LoRusso P, Sailer R, Busse D.

03.06.25

Exposure-response analysis for time-to-event data in the presence of adaptive dosing: efficient approaches and pitfalls

ConferenceMethodologyMIDDTrial design and analysis

PAGE 33 (2025) Abstr 11525

Lavalley-Morelle A, Le Louedec F, Anziano R, Mentré F, Bergstrand M.

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Below we provide links to posters, white papers and scientific publications by Pharmetheus affiliates in chronological order. Please note that access to some publications may require a subscription.

Featured Publications

Exposure‐tumour growth inhibition modelling of brigimadlin using phase I solid tumour data to support phase II dose selection

The reference corrected VPC (rcVPC) – an informative model diagnostics for assessing underying exposure-response relationships

Assessing Drug–Drug Interaction and Food Effect for BCS Class 2 Compound BI 730357 (Retinoic Acid-Related Orphan Receptor Gamma Antagonist, Bevurogant) Using a Physiology-Based Pharmacokinetics Modeling (PBPK) Approach with Semi-Mechanistic Absorption

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Publications 5 of 214

Featured Publications

Exposure‐tumour growth inhibition modelling of brigimadlin using phase I solid tumour data to support phase II dose selection

The reference corrected VPC (rcVPC) – an informative model diagnostics for assessing underying exposure-response relationships

Assessing Drug–Drug Interaction and Food Effect for BCS Class 2 Compound BI 730357 (Retinoic Acid-Related Orphan Receptor Gamma Antagonist, Bevurogant) Using a Physiology-Based Pharmacokinetics Modeling (PBPK) Approach with Semi-Mechanistic Absorption

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Publications 5 of 214

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