Niclas Jonsson, Ph.D.

Principal Consultant, Scientific Director & Pharmacometrics Platform Scientific Lead


  • Co-founded Pharmetheus in 2012, actively working in client projects, serving as Scientific Director, deputy Chief Research Officer, and Pharmacometrics Platform Lead
  • Expertise includes pharmacometrics and its applications across therapeutic areas
  • Previously worked as Senior Consultant at Exprimo NV, Sweden, where he interacted with clients and provided pharmacokinetic, pharmacodynamic, and disease modeling and simulation services to drug development programs in various therapeutic areas, as Global Head of Modeling and Simulation at Hoffman-La Roche, Switzerland, Associate Professor of Applied Pharmacometrics and Senior Lecturer at Uppsala University, and as Postdoctoral Researcher at University of California San Francisco, USA. Co-developer of the software programs Xpose 4 and PsN
  • M.Sc. in Pharmacy (1991) and Ph.D. in Biopharmaceutical Sciences (1998) from Uppsala University, Sweden
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Pharmetheus affiliated publications

Using forest plots to interpret covariate effects in pharmacometric modelsProperties of the full random-effect modeling approach with missing covariate dataEfficient and relevant stepwise covariate model building for pharmacometrics [2]Checklists and best practices to support the informed use of Forest plots to illustrate the impact of covariates in pharmacometric modelsWriting reports of modelling and simulation analysis: Our experience in the field of pharmacometricsAn Introduction to the Full Random Effects ModelPopulation Pharmacokinetic Analysis of Tepotinib, an Oral MET Kinase Inhibitor, Including Data From the VISION StudyEfficient and relevant stepwise covariate model building for pharmacometrics [1]A Quantitative Approach to the Choice of Number of Samples for Percentile Estimation in Bootstrap and Visual Predictive Check AnalysesConditional Distribution Modeling as an Alternative Method for Covariates Simulation: Comparison with Joint Multivariate Normal and Bootstrap TechniquesLumenfantrine Exposure in Malnourished Children: PBPK Modeling Applied for Predictions and Dose Adjustments