Quantitative approaches to drug development

We provide consultancy services to help our clients reduce uncertainty in research and regulatory questions, increasing confidence in the development of new medicines that can improve patients’ lives.

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17.10.2024
Population pharmacokinetic and dose–response models of nepadutant, a selective antagonist of the NK₂ receptors, in infants with colic

Current treatments in infantile colic are insufficient, with inadequate efficacy or intolerableside-effects. Nepadutant, a tachykinin NK₂ receptor antagonist, was considered a promisingcandidate through its mechanism of action and for its potential to be dosed orally in infants. In a new publication the pharmacokinetics and exposure–response (durationof crying and fussing) following treatment with nepadutant were described in infants (4-20weeks) with colic. Read more about this…

23.09.2024
New publication: PBPK analysis supports dose selection for a sustained-release 5-FC for improved CM treatment in HIV patients

The publication focuses on a novel treatment for Cryptococcal meningoencephalitis (CM), a leading cause of death among people living with HIV in sub-Saharan Africa. Current treatment with 5-flucytosine (5-FC) poses significant challenges due to its short half-life and complicated dosing schedule, risking patient compliance.

04.09.2024
Pharmetheus passes 100 employees and moves to new office in central Uppsala

Pharmetheus AB is happy to announce two significant events, highlighting its capacity and future ambitions. The company has organically grown its team past 100 employees, and is relocating its headquarters to a sustainability flagship in central Uppsala, allowing for an easy commute for the employees and its global clients. CEO, Peter Milligan, reflects on the development: – When I joined…

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Model Informed Drug Development

A quantitative framework to support and inform development program strategies and decisions.

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“Sharing with colleagues is why I love working here”

Sophie Peigné supports clients with expert and strategic advice in pharmacometrics as well as hands-on modeling analyses for compounds in all development phases.

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History of Pharmetheus

Our journey is an exciting one. We began as a start-up that spinned off from Uppsala University. Today, we have grown into a global medium-sized company, adding value to drug development each day.

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