Publications

03.06.25

Physiologically based predictions of monoclonal antibody pharmacokinetics: insights from a large-scale data analysis

ConferencePBPK/PBBMProgram strategies and efficienciesSpecial considerations

PAGE 33 (2025) Abstr 11791

Benamara S, Sjogren E, Gattacceca F, Chenel M, Deslandes A, Nguyen L, Teutonico D.

03.06.25

Development of efficient CAR-T cell clinical study designs: Towards understanding of novel anticancer therapies through optimal experimental design

ConferenceMethodologyOncologyPharmacometricsTrial design and analysis

PAGE 33 (2025) Abstr 11783

Klima F, Mc Laughlin AM, Michelet R, Winkler A, Huisinga W, Haussmann K, Künkele A, Hooker AC, Kloft C..

03.06.25

Application of model-informed drug development for dose optimization of brigimadlin in patients with dedifferentiated liposarcoma

ConferenceMIDDOncologyPharmacometricsPhase IPhase IIPhase IIIProgram strategies and efficienciesTrial design and analysis

PAGE 33 (2025) Abstr 11666

Aguiar Zdovc J, Gausi K, Langenhorst J, Yin A, Acharya C, Sarr C, Friberg LE, Lahmar M, Grempler R, Pérez-Pitarch A, Schmid U, LoRusso P, Sailer R, Busse D.

03.06.25

Exposure-response analysis for time-to-event data in the presence of adaptive dosing: efficient approaches and pitfalls

ConferenceMethodologyMIDDTrial design and analysis

PAGE 33 (2025) Abstr 11525

Lavalley-Morelle A, Le Louedec F, Anziano R, Mentré F, Bergstrand M.

03.06.25

Expediting MIDD evidence generation to support quizartinib approval in newly diagnosed AML patients

ConferenceMIDDOncologyPhase IIIProgram strategies and efficienciesRegulatory interactions

PAGE 33 (2025) Abstr 11445

Glatard A, Mezzalana E, Zheng M, Bergstrand M, Smania G.

Cookie	Duration	Description
__cf_bm	1 hour	This cookie, set by Cloudflare, is used to support Cloudflare Bot Management.
__hssc	1 hour	HubSpot sets this cookie to keep track of sessions and to determine if HubSpot should increment the session number and timestamps in the __hstc cookie.
__hssrc	session	This cookie is set by Hubspot whenever it changes the session cookie. The __hssrc cookie set to 1 indicates that the user has restarted the browser, and if the cookie does not exist, it is assumed to be a new session.
_cfuvid	session	Calendly sets this cookie to track users across sessions to optimize user experience by maintaining session consistency and providing personalized services
cookielawinfo-checkbox-advertisement	1 year	Set by the GDPR Cookie Consent plugin, this cookie records the user consent for the cookies in the "Advertisement" category.
cookielawinfo-checkbox-analytics	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional	11 months	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
CookieLawInfoConsent	1 year	CookieYes sets this cookie to record the default button state of the corresponding category and the status of CCPA. It works only in coordination with the primary cookie.
viewed_cookie_policy	11 months	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
wpEmojiSettingsSupports	session	WordPress sets this cookie when a user interacts with emojis on a WordPress site. It helps determine if the user's browser can display emojis properly.

Cookie	Duration	Description
__hstc	6 months	Hubspot set this main cookie for tracking visitors. It contains the domain, initial timestamp (first visit), last timestamp (last visit), current timestamp (this visit), and session number (increments for each subsequent session).
_pk_id.*	1 year 27 days	Matamo set this cookie to store a unique user ID.
_pk_ses.*	30 minutes	Matomo set this cookie to store a unique session ID for gathering information on how the users use the website.
CONSENT	2 years	YouTube sets this cookie via embedded YouTube videos and registers anonymous statistical data.
hubspotutk	6 months	HubSpot sets this cookie to keep track of the visitors to the website. This cookie is passed to HubSpot on form submission and used when deduplicating contacts.

Cookie	Duration	Description
VISITOR_INFO1_LIVE	5 months 27 days	YouTube sets this cookie to measure bandwidth, determining whether the user gets the new or old player interface.
YSC	session	Youtube sets this cookie to track the views of embedded videos on Youtube pages.
yt-remote-connected-devices	never	YouTube sets this cookie to store the user's video preferences using embedded YouTube videos.
yt-remote-device-id	never	YouTube sets this cookie to store the user's video preferences using embedded YouTube videos.

Cookie	Duration	Description
__cflb	23 hours	This cookie is used by Cloudflare for load balancing.
_pk_id.1.2941	1 year 27 days	Description is currently not available.
_pk_ses.1.2941	30 minutes	Description is currently not available.

Below we provide links to posters, white papers and scientific publications by Pharmetheus affiliates in chronological order. Please note that access to some publications may require a subscription.

Featured Publications

Exposure‐tumour growth inhibition modelling of brigimadlin using phase I solid tumour data to support phase II dose selection

The reference corrected VPC (rcVPC) – an informative model diagnostics for assessing underying exposure-response relationships

Assessing Drug–Drug Interaction and Food Effect for BCS Class 2 Compound BI 730357 (Retinoic Acid-Related Orphan Receptor Gamma Antagonist, Bevurogant) Using a Physiology-Based Pharmacokinetics Modeling (PBPK) Approach with Semi-Mechanistic Absorption

Search Publications

Publications 5 of 211

Featured Publications

Exposure‐tumour growth inhibition modelling of brigimadlin using phase I solid tumour data to support phase II dose selection

The reference corrected VPC (rcVPC) – an informative model diagnostics for assessing underying exposure-response relationships

Assessing Drug–Drug Interaction and Food Effect for BCS Class 2 Compound BI 730357 (Retinoic Acid-Related Orphan Receptor Gamma Antagonist, Bevurogant) Using a Physiology-Based Pharmacokinetics Modeling (PBPK) Approach with Semi-Mechanistic Absorption

Search Publications

Publications 5 of 211

Related content

Science and Services

Case studies

Scientific Publication