Publications

15.07.26

Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling

JournalPBPK/PBBMRegulatory interactions

CPT: Pharmacometrics & Systems Pharmacology, 2026 July; 15(7)

Chenel M, Dallmann A, Ince I, Meyer M, Schlender JF, Teutonico D, Sjögren E.

25.06.26

Accelerating subcutaneous drug development: A mechanistic absorption model for the Open Systems Pharmacology framework

JournalMethodologyPBPK/PBBM

CPT Pharmacometrics Syst Pharmacol. 2026 Jul;15(7):e70292.

Pellowe M, Dubbelboer I, Sjögren E.

04.06.26

Model-integrated evidence: A vision to expand the role of modeling in drug development and regulatory decision-making

JournalMIDDPBPK/PBBMPharmacometricsProgram strategies and efficienciesQSPRegulatory interactions

Quant Med. 2026;1(1). Online ahead of print.

Zhao L, Mondick J, Barrett J, Bhattacharya S, Chenel M, Corrigan B, Dutta S, Gao W, Gao X, Girish S, Hooker AC, Jones H, Langevin B, Peck C, Rostami-Hodjegan A, Sun YN, Lovern M.

04.06.26

Large Language Model-Supported Data Collation: Addressing Accuracy and Reproducibility

AutomationImmunologyJournalMethodology

Quant Med. 2026;1(1):16-26. Online ahead of print.

Sellen S, Sjögren E.

02.06.26

Food effect prediction of high permeability/low solubility, formulated as an amorphous solid dispersion (ASD) using an open systems pharmacology (OSP) PBBM approach

ConferencePBPK/PBBMPharmacometricsPhase ISpecial considerations

PAGE 34 (2026) Abstr 12084

Vrenken P, Lambert M, Mezzalana E, Eriksson J, Fouliard S, Sjögren E.

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Featured Publications

Risks encountered when not adjusting for diurnal variation and food effect in QTcF analysis based on Phase I data

Exposure-response analysis for time-to-event data in the presence of adaptive dosing: efficient approaches and pitfalls

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Featured Publications

Risks encountered when not adjusting for diurnal variation and food effect in QTcF analysis based on Phase I data

Exposure-response analysis for time-to-event data in the presence of adaptive dosing: efficient approaches and pitfalls

Population Pharmacokinetics and Exposure‐Response Model‐Based Bayesian Extrapolation of FVC‐Based Efficacy Endpoints From Adults to Pediatric Patients Receiving Nintedanib

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Publications 5 of 265

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