Giovanni Smania, Ph.D.

Senior Consultant, MIDD Platform Business Development Lead & Team Leader


  • Joined Pharmetheus in 2018, actively working in client projects, serving as Project Portfolio Team Leader and Platform Business Development Lead
  • Expertise includes MIDD in early and late phase projects in therapeutic areas such as oncology and cardiometabolic disease
  • Previously worked as Clinical Pharmacology and Pharmacometrics Specialist at Menarini Ricerche, Italy, and as Research Fellow at CVBF, Italy
  • M.Sc. in Bioengineering (2013) from University of Padova, Italy, and Ph.D. in Pharmacometrics (2017) from University of Pavia, Italy
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Pharmetheus affiliated publications

Concentration-QTcF Analysis of Quizartinib in Patients With Newly Diagnosed (ND) Acute Myeloid Leukemia (AML)Population Pharmacokinetics (PopPK) of Quizartinib and Its Active Metabolite AC886 in Patients (Pts) With Newly Diagnosed (ND) Acute Myeloid Leukemia (AML)Exploring the relationship between BI 456906 exposure and change in fasting plasma glucose, fasting serum insulin, and glycated hemoglobin (HbA1c) using population PKPD modelingConditional Distribution Modeling as an Alternative Method for Covariates Simulation: Comparison with Joint Multivariate Normal and Bootstrap TechniquesInvestigating the Identifiability of One-Stage IVIVC Population Models for Extended-Release Dosage FormsConditional Distribution Modeling for Covariates Simulation Using Classification and Regression Trees Methods