Jurgen Langenhorst, Ph.D.

Senior Consultant & Team Leader


  • Joined Pharmetheus in 2019, actively working in client projects and serving as Project Portfolio Team Leader
  • Expertise includes item-response theory, pediatrics, QTc analysis, and clinical pharmacology in therapeutic areas such as immunology and oncology
  • Previously worked as Production Pharmacist at the University Medical Center Utrecht, the Netherlands, where he supported daily practice in the manufacturing department of the pharmacy
  • M.Sc. in Pharmacy (2015) from Utrecht University, the Netherlands, and Ph.D. in Pharmaceutics (2019) from the University Medical Centre Utrecht, the Netherlands

Pharmetheus affiliated publications

An Item Response Theory Model with Bounded Integer Subcomponents to Describe the Mayo Clinic Subscores in Patients with Ulcerative Colitis [2]A platform for mechanistic modelling of subcutaneous administration with the effect of immunogenicity within the Open Systems Pharmacology frameworkA disease model predicting placebo response and remission status of patients with ulcerative colitis using modified Mayo scoreHow to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an ExamplePopulation Pharmacokinetics of Tenecteplase in Patients With Acute Myocardial Infarction and Application to Patients With Acute Ischemic StrokeConcentration QTc Analysis of Giredestrant: Overcoming QT/heart rate Confounding in the Presence of Drug-Induced Heart Rate ChangesA Semi-Mechanistic Model Based on Glutathione Depletion to Describe Intra-Individual Reduction in Busulfan ClearanceClinical Trial Simulation To Optimize Trial Design for Fludarabine Dosing Strategies in Allogeneic Hematopoietic Cell TransplantationExposure-Response Analysis of Etrolizumab in Patients with Moderately-to-severely Active Ulcerative Colitis