Workshop: Learn and apply TTE and RTTE modeling with a focus on NONMEM
Join our interactive Time-to-Event (TTE) and Repeated TTE (RTTE) modeling workshop in NONMEM on June 2-3, in connection with PAGE 2025. This workshop covers theoretical concepts, hands-on NONMEM coding, exposure-response relationships, survival analysis, and graphical communication. Key speakers: France Mentré, Lena Friberg, and Nastya Kassir. Early bird pricing available—register by April 1.
Satellite meeting overview
Workshop in connection to PAGE 2025, Thessaloniki, Greece
This one-and-a-half-day workshop provides a comprehensive introduction to time-to-event (TTE) and repeated TTE (RTTE) modeling in NONMEM, covering both theoretical concepts and practical applications.
Audience
The workshop is designed for students and pharmacometricians with little to no prior experience in TTE/RTTE modeling.
Learning objective
Participants engage with and learn from industry and academic experts through lectures and discussions. By the end of the workshop, attendees will be able to understand, conduct, and effectively communicate TTE and RTTE modeling analyses.
Early bird price applies by 1 April – sign up now
Register your participation in the workshop to secure a spot
Key topics covered
- TTE & RTTE fundamentals – Key concepts and applications
- Data preparation & visualization – Formatting and graphical exploration
- NONMEM coding & model development – Parameterization, exposure-response, covariates
- Simulation frameworks – NONMEM strategies & graphical communication
- Evaluation & diagnostics – Hands-on model performance analysis
- Survival analysis in drug development – Insights from industry & academia
Workshop agenda
Outline of Day 1
Monday 2nd June
Afternoon, 13:00-17:00
- Detailed insights to NONMEM code useful for the model development, such as standard and alternative function parameterization, implementation of exposure-response relationships and estimation of covariate effects.
Outline of Day 2
Tuesday 3rd June
Morning, 08:00-12:00
- Continuation of NONMEM coding for model development
- Overview of efficient simulation frameworks will be presented, with a focus on NONMEM coding and derived metrics to graphically communicate on. *
- Several hands-on sessions to help the attendees appreciate the specificities of TTE/RTTE models in terms of evaluation and diagnostics.
Afternoon 13:00-17:00*
- Motivation for running survival analyses from a model-informed drug development perspective, with key speakers from academia and industry: France Mentre, Lena Friberg and Nastya Kassir.
*The afternoon of the second day is free-of-charge for attendees of the previous sessions.
Workshop faculty
Key speakers
- Co-founded Pharmetheus in 2012, advising in client projects and training Pharmetheus colleagues in pharmacometrics
- Expertise includes development of pharmacokinetic-pharmacodynamic models of desired and adverse effects in therapeutic areas such as oncology, infectious diseases, and neuroscience
- Experience as Professor of Pharmacometrics (2014-2021) and Pharmacokinetics and Pharmacodynamics (2021- ) at Uppsala University, Sweden, where she performs research and teaches in pharmacokinetics, pharmacodynamics, pharmacometrics, and drug development. Previously, she worked as Research Fellow and Associate Professor at Uppsala University, Sweden, and Postdoctoral Research Fellow at University of Queensland, Australia
- M.Sc. in Pharmaceutical Sciences (1997) and Ph.D. in Pharmacokinetics and Drug Therapy (2003) from Uppsala University, Sweden
- Collaborating with Pharmetheus since 2022, in the role as a Scientific Advisor
- Expertise includes Biostatistical Modelling and Pharmacometrics for treatment of Infectious Diseases, and development of the software PFIM for optimal design in pharmacometrics
- Currently Professor of Biostatistics at University Paris Cité, France, editor in Chief of CPT: Pharmacometrics and System Pharmacology since 2018, and co-founder of the Special Interest Group on Statistics and Pharmacometrics of ASA and ISoP
- M.Sc. in Mathematics (1984) from École Normale Supérieure, Ph.D. in Biomathematics (1984) from University Paris 6, M.D. (1993) from University Paris 7, France
- Currently serves as Senior Director & Distinguished Scientist in clinical pharmacology, modeling & simulation at Genentech/Roche, providing M&S scientific oversight for most of the non-oncology portfolio and ~40% of the oncology portfolio.
- Wide range of M&S experience and expertise for SMs and biologies in diverse therapeutic areas from Phase I to post-marketing, including rich global filing and health authority interaction experience.
- Previously worked as M&S consultant at Certara/Pharsight for ~ 13 years, most recently as Senior Director responsible for scientific oversight and business relationship management/expansion.
- Pharm.D. (2005) from Lebanese University, Lebanon and a Ph.D. in Pharmaceutical Sciences, Pharmacometrics (2013) from the University of Montreal, Canada
Workshop tutors
Event details and sign up
Date and time
Monday 2nd June – Tuesday, 3rd June, 2025
- 1st day 13.00-17.00
- 2nd day 8.00-17.00
Location
- Venue: Thessaloniki, Greece. Exact location TBC
Fees
- Commercial/Industry: 950 (750*) EUR excl. VAT.
- Academia/government/non for profit: 500 (450*) EUR excl. VAT.
- Students: 250 (200*) EUR excl. VAT.
Coffee break both days and lunch 3rd June are included
* Early bird: The reduced early bird price applies to registrations made by 1st April.
Registration – secure your spot
Learn and apply TTE and RTTE modeling with a focus on NONMEM