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Gianluca Selvaggio

Gianluca Selvaggio

Gianluca Selvaggio, Ph.D.

Director, MIDD Consultant

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Joined Pharmetheus in 2023, actively working in client projects and with continuous improvement
Expertise includes mathematical modeling of biological processes in the quantitative systems pharmacology field in therapeutic areas such as oncology and immuno-inflammation
Previously worked as Senior Modeler at the Fondazione Microsoft Research - University of Trento Centre for Computational and Systems Biology, where he also served as Project Leader
M.Sc. in Biomedical engineering (2010) from University of Bologna, Italy, and Ph.D. in Bioengineering (2016) from the New University of Lisbon, Portugal

Pharmetheus affiliated publications

Benchmarking a mechanistic immunogenicity framework: aligning sequence-based epitope predictions with clinical observations Integrating in silico epitope prediction and mechanistic QSP modeling for benchmarking immunogenicity risk A novel model for Platelets Dynamics: a pragmatic systems approach to characterize thrombocytopenia across multiple compounds and drug classes A quantitative systems pharmacology framework of immunogenicity to propose mitigation strategies after subcutaneous administration Absorption, Bioavailability, and Immunogenicity after Subcutaneous Administration: Evaluation of a Subcutaneous Platform within the Open Systems Pharmacology framework Physiologically based pharmacokinetic modelling to support design of microarray patches delivering antiretroviral drugs to HIV positive children. Use of quantitative systems pharmacology pipelines to bridge in vitro and in vivo results in drug discovery Mechanistic modelling of bioavailability and local immunogenicity after subcutaneous administration within the Open Systems Pharmacology framework

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Pharmetheus is a consultancy firm helping clients reduce uncertainty in technical and regulatory processes, increasing confidence in the development of new medicines that can improve patients’ lives.

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