Development of a Physiologically-Based Pharmacokinetic Model for Coproporphyrin I (CP-I) Using the Open Systems Pharmacology Software Suite (PK-Sim and MoBi) for assessment of OATP1B-based DDIs

ACoP14 (Nov 2023), Poster: W-071

Kanacher T, Pellowe M, Kovar C, Eriksson J, Huang F, Wu F, Sailer R, Busse D, Gómez-Mantilla JD.

This poster describes a Coproporphyrin (CP-I) PBPK-model, which can be used in the freely accessible Open Systems Pharmacology Suite (PK-Sim and MoBi) to assess potential drug-drug interaction of new therapeutic drugs via OATP1B.

Pharmetheus Affiliates

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Pharmetheus Affiliates

Tobias Kanacher

Moriah Pellowe

Christina Kovar

Johanna Eriksson