PAGE 2026 workshop: PBPK & PBBM – linking biopharmaceutics to clinical performance with OSP suite

Do you want to increase your capabilities to support decision-making in drug development with physiologically-based pharmacokinetics (PBPK) and physiologically-based biopharmaceutics modeling (PBBM)?

Satellite meeting overview

This one-day workshop will give you the necessary experience in using and leveraging the Open Systems Pharmacology (OSP) suite to link biopharmaceutics properties to clinical performance and address formulation-related questions throughout drug development.

Key topics covered

The workshop will involve both the standardized, well-established whole-body PBPK model provided in PK-Sim® and the open modeling capabilities in MoBi®, together with specialized R packages.

The workshop covers aspects such as:
The fundamentals in PK-Sim and MoBi
Set up for oral PBBM in PK-Sim
Analyses and integration of in vitro dissolution and permeability data leveraging R-packages and MoBi
Predictions of clinical performance (PK) and relative bioavailability based on biopharmaceutics drug properties
Predictions of food effects to inform study designs and support labelling
Predictions of drug-drug interactions mediated by changes to gastric pH (e.g., Proton Pump Inhibitors)

The workshop involves lectures, hands-on sessions, and demos. Hands-on sessions on dissolution and permeability modeling will use the latest version of R packages based on the PBBM framework developed by Vrenken et al.