PAGE 2026 workshop: PBPK & PBBM – linking biopharmaceutics to clinical performance with OSP suite 

Attend an online half-day or full-day on-site. This workshop will give you the experience you need to use and leverage the Open Systems Pharmacology (OSP) suite to link biopharmaceutics properties to clinical performance and address formulation-related questions throughout drug development, thereby increasing your capabilities to support decision-making in drug development.

The workshop will involve both the standardized, well-established whole-body PBPK model provided in PK-Sim® and the open modeling capabilities in MoBi®, together with specialized R packages.

• The workshop covers aspects such as:
• The fundamentals in PK-Sim and MoBi
• Set up for oral PBBM in PK-Sim 
• Analyses and integration of in vitro dissolution and permeability data leveraging R-packages and MoBi 
• Predictions of clinical performance (PK) and relative bioavailability based on biopharmaceutics drug properties
• Predictions of food effects to inform study designs and support labelling
• Predictions of drug-drug interactions mediated by changes to gastric pH (e.g., Proton Pump Inhibitors)

The workshop is structured as a hybrid event. The morning session will feature a lecture and live demonstration, open to both on-site and remote participants. The afternoon session will be a hands-on workshop focused on dissolution and permeability modeling, available exclusively for those attending on-site. The hands-on component will utilize the latest version of R packages based on the PBBM framework developed by Vrenken et al.