Workshop at ACoP 2026 – (R)TTE analysis: MIDD applications, concept, methodology and NONMEM hands-on
Join our experts for an interactive 1.5 workshop in connection to ACoP 17, on how to make the best use of TTE and RTTE modeling in NONMEM. The workshop will include several hands-on sessions to help the attendees appreciate specificities of TTE/RTTE models in terms of evaluation and diagnostics.
Workshop overview
The workshop’s objective is to provide a good understanding of time to event (TTE) and repeated TTE (RTTE) modeling in NONMEM, in theory and practice, by listening to and discussing with leaders from industry and academia.
Target audience
Pharmacometricians with no, or limited, experience of TTE/RTTE modeling, and students.
Key topics covered
- The motivation for running survival analyses from a model-informed drug development perspective with key speakers from academia and industry (day one is free of charge),
- an introduction to general concepts and theory, typical TTE/RTTE analysis followed by data formatting and key aspects of graphical exploration of TTE/RTTE data,
- detailed insights to NONMEM code useful for the model development, such as standard and alternative function parameterization, implementation of exposure-response relationships and estimation of covariate effects,
- an overview of efficient simulation frameworks, with a focus on NONMEM coding and derived metrics, using graphs for communication,
- several hands-on sessions to help you grasp the specificities of TTE/RTTE models in terms of evaluation and diagnostics.
Learning objectives
After the workshop you will be able to understand, conduct and communicate TTE and RTTE modeling analyses.
Workshop faculty
Key speakers
- Co-founded Pharmetheus in 2012, advising in client projects and training Pharmetheus colleagues in pharmacometrics
- Expertise includes development of pharmacokinetic-pharmacodynamic models of desired and adverse effects in therapeutic areas such as oncology, infectious diseases, and neuroscience
- Experience as Professor of Pharmacometrics (2014-2021) and Pharmacokinetics and Pharmacodynamics (2021- ) at Uppsala University, Sweden, where she performs research and teaches in pharmacokinetics, pharmacodynamics, pharmacometrics, and drug development. Previously, she worked as Research Fellow and Associate Professor at Uppsala University, Sweden, and Postdoctoral Research Fellow at University of Queensland, Australia
- M.Sc. in Pharmaceutical Sciences (1997) and Ph.D. in Pharmacokinetics and Drug Therapy (2003) from Uppsala University, Sweden
- Collaborating with Pharmetheus since 2022, in the role as a Scientific Advisor
- Expertise includes Biostatistical Modelling and Pharmacometrics for treatment of Infectious Diseases, and development of the software PFIM for optimal design in pharmacometrics
- Currently Professor of Biostatistics at University Paris Cité, France, editor in Chief of CPT: Pharmacometrics and System Pharmacology since 2018, and co-founder of the Special Interest Group on Statistics and Pharmacometrics of ASA and ISoP
- M.Sc. in Mathematics (1984) from École Normale Supérieure, Ph.D. in Biomathematics (1984) from University Paris 6, M.D. (1993) from University Paris 7, France
- Currently a Senior Principal Scientist in the Modeling and Simulation (M&S) group at Genentech, Inc.
- Recent expertise and contributions include development of pharmacokinetic and pharmacokinetic-pharmacodynamic models for molecules in Genentech’s bispecific drug and antibody drug conjugate (ADC) portfolios.
- Employed at Genentech since 2003, with key M&S filing contributions for the ocular drug Lucentis (2006), the ADC drug Kadcyla (2013), and the bispecific drug Lunsumio (2022).
- M.Sc. in Pharmaceutical Sciences (2003) from UNC-Chapel Hill and Ph.D. in Pharmaceutical Biosciences (2016) from Uppsala University, Sweden
Workshop tutors
Event details and registration
Date and time
Thursday October 15 – Friday October 16, 2026
- 1st day 1PM – 5 PM (free of charge)
- 2nd day 8.30 PM – 4 PM
Fees
- Non-member (ISOP): 1000 (850*) USD.
- Member (ISOP): 800 (700*) USD.
- Student/trainee: 650 (550*) USD.
Coffee break both days and lunch on day 2 are included
* Early bird: The reduced early bird price applies to registrations made by September 15.
Registration – secure your spot
Learn and apply TTE and RTTE modeling with a focus on NONMEM