Giovanni Smania, Ph.D.

Senior Consultant


  • Joined Pharmetheus in 2018, actively working in client projects, with continuous improvements, and serving as Deputy Project Portfolio Team Leader.
  • Expertise includes pharmacometrics (especially translational models, model informed precision dosing and covariate analysis), model informed drug development and in-vitro in-vivo correlation in therapeutic areas such as oncology, neuroscience, and hematology.
  • Experience as Clinical Pharmacology and Pharmacometrics Specialist at Menarini Ricerche, Italy, where he supported early clinical development of products in oncology. Previously, he worked as Collaborator and Research Fellow at CVBF, Italy.
  • M.Sc. in Bioengineering (2013) and Ph.D. in Bioengineering and Bioinformatics (2017) from University of Pavia, Italy.
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Pharmetheus affiliated publications

Exploring the relationship between BI 456906 exposure and change in fasting plasma glucose, fasting serum insulin, and glycated hemoglobin (HbA1c) using population PKPD modelingConditional Distribution Modeling as an Alternative Method for Covariates Simulation: Comparison with Joint Multivariate Normal and Bootstrap TechniquesInvestigating the Identifiability of One-Stage IVIVC Population Models for Extended-Release Dosage FormsConditional Distribution Modeling for Covariates Simulation Using Classification and Regression Trees Methods