Coproporphyrin I PBPK model in the open systems pharmacology suite enables precise prediction of OATP 1B- mediated drug interactions through calibrated In vivo inhibition constants

Front. Pharmacol. 2026;17:1828033
Kanacher T, Pellowe M, Kovar C, Eriksson J, Wu J, Busse D, Gómez-Mantilla JD, Stopfer P, Ince I, Huang F.
DDIJournalPBPK/PBBMProgram strategies and efficienciesRegulatory interactionsTrial design and analysis

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Tobias Kanacher

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Moriah Pellowe

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Christina Kovar

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