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  1. Home
  2. Publications

Publications

Below we provide links to posters, white papers and scientific publications by Pharmetheus affiliates in chronological order. Please note that access to some publications may require a subscription.

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Publications

18.09.24

Bioavailability of a novel sustained-release pellet formulation of 5-flucytosine in healthy-fed participants for use in patients with cryptococcal meningitis

PBPK & PBBM

Infectious Diseases

Clin Transl Sci. 2024; 17:e13908

Ibnou Zekri Lassout N, Goyal V, Krantz E, Simon F, Neven A, Eriksson J, Saayman A, Satam V, Ruffell C, Victor S, Chenel M, Celebic A, Caplain H, Gillon J-Y, Deshmukh A, Antarkar A, Sjögren E, Ribeiro I

16.09.24

PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space

PBPK & PBBM

Hematology

CPT Pharmacometrics Syst Pharmacol. 2024 Sep 16.

Cloesmeijer ME, Sjögren E, Koopman SF, Lenting PJ, Cnossen MH, Mathôt RAA; OPTI‐CLOT study group and SYMPHONY consortium.

27.06.24

Full random effects models (FREM): A practical usage guide

Pharmacometrics

Methodology

CPT Pharmacometrics Syst Pharmacol. 2024 Aug;13(8):1297-1308.

Jonsson EN, Nyberg J

25.06.24

A workflow for evaluating and optimizing the designs of paediatric studies

Specific populations

Pharmacometrics

PAGE 32 (2024) Abstr 11082

Ibrahim MMA, Hansson E, Hooker AC, Bergstrand M

25.06.24

Development of a PBPK model to predict monoclonal antibody pharmacokinetics and bioavailability following subcutaneous administration

PBPK & PBBM

PAGE 32 (2024) Abstr 10780

Benamara S, Teutonico D, Gattacceca F, Nguyen L, Deslandes A, Chenel M, Sjögren E

25.06.24

Physiologically-based pharmacokinetic (PBPK) modeling to predict disease effects on 5-flucytosine pharmacokinetics (PK) in the context of a switch from an immediate release (IR) to a sustained release (SR) formulation.

PBPK & PBBM

Specific populations

Infectious Diseases

PAGE 32 (2024) Abstr 10899

Eriksson J, Sjögren E, Gillon JY, Goyal V, Satam V, Robinson S, Caplain H, Ribeiro I, Chenel M

25.06.24

A Physiologically Based Pharmacokinetic Model of Atorvastatin Acid Predicting CYP3A4 and OATP1B Drug–Drug Interactions

PBPK & PBBM

PAGE 32 (2024) Abstr 10834

Kovar C, Kanacher T, Huang F, Wu J, Sailer R, Busse D, Gómez-Mantilla JD, Ince I

25.06.24

The reference corrected VPC – A more intuitive model diagnostic

Pharmacometrics

Methodology

PAGE 32 (2024) Abstr 11053

Ibrahim MMA, Jonsson EN, Bergstrand M

1 …121314… 34

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About Pharmetheus

Pharmetheus is a consultancy firm helping clients reduce uncertainty in technical and regulatory processes, increasing confidence in the development of new medicines that can improve patients’ lives.

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