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Publications

Below we provide links to posters, white papers and scientific publications by Pharmetheus affiliates in chronological order. Please note that access to some publications may require a subscription.

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11.11.24

Exposure-efficacy analysis of datopotamab deruxtecan (Dato-DXd), a TROP2-directed antibody-drug conjugate, in patients with advanced non-small cell lung cancer

Oncology

Trial design and analysis

Pharmacometrics

ACoP15 (Nov 2024), Poster: M-074

Mc Laughlin AM, Pan Y, Friberg Hietala S, Peigné S, Uema D, Zwirtes R, Dai D, Zhou D, Tajima N, Garimella T, Abutarif M, Hong Y

11.11.24

Phase 1 interim population PK/PD modeling and recommended phase 2 dose exploration for IMM-1-104: A novel concept oral deep cyclic inhibitor of MEK

Oncology

MIDD

Trial design and analysis

Pharmacometrics

ACoP 15 (Nov 2024), Poster: W-019

Yamamura A, Axel A, King P, Funt J, Foley EM, Kovar C, Bergstrand M, Mezzalana E, Chenel M, Hayreh V, Hall B

11.11.24

Physiologically based pharmacokinetic modelling to support the development of a sustained-release formulation for the treatment of cryptococcal meningoencephalitis: An MIDD case study

PBPK & PBBM

MIDD

Specific populations

Infectious Diseases

Program strategies and efficiencies

ACoP15 (Nov 2024), Poster: W-029

Eriksson J, Sjögren E, Gillon JY, Goyal V, Satam V, Robinson S, Caplain H, Ribeiro I, Chenel M

11.11.24

The reference corrected VPC (rcVPC) - an informative model diagnostics for assessing underying exposure-response relationships

Pharmacometrics

Methodology

ACoP15 (Nov 2024), Poster: W-008

Ibrahim MMA, Jonsson EN, Bergstrand M

16.10.24

A workflow for comparing drug candidates based on Probability of Pharmacological Success (PoPS)

MIDD

Program strategies and efficiencies

Automation

GMP Symposium 2024

Leirens Q, Ibrahim MMA, Bergstrand M

16.10.24

Optimizing Formulations for Treatment of Cryptococcal Meningoencephalitis in Sub-Saharan HIV Patients: Insights from PBPK Modeling

Oral presentation, GMP Symposium 2024

Eriksson J, Sjögren E, Gillon JY, Goyal V, Robinson S, Caplain H, Ribeiro I, Chenel M

16.10.24

A quantitative systems pharmacology framework of immunogenicity to propose mitigation strategies after subcutaneous administration

Methodology

Oral presentation, GMP Symposium 2024

Selvaggio G, Pellowe M, Chenel M, Sjögren E

26.09.24

Population pharmacokinetic and dose–response models of nepadutant, a selective antagonist of the NK₂ receptors, in infants with colic

Trial design and analysis

Specific populations

Pharmacometrics

Gastroenterology

Br J Clin Pharmacol. 2024 Sep 26. Online ahead of print.

Jönsson S, Bouchene S, Mazzei P, Borella E, Piana C, Tagliavini A, Koletzko S, Werkstetter K, Capriati A, Pellacani A, Karlsson MO, Jonsson EN

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