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09.08.26

Coproporphyrin I PBPK model in the open systems pharmacology suite enables precise prediction of OATP 1B- mediated drug interactions through calibrated In vivo inhibition constants

PBPK & PBBM

Program strategies and efficiencies

Trial design and analysis

Regulatory interactions

Front. Pharmacol. 2026;17:1828033

Kanacher T, Pellowe M, Kovar C, Eriksson J, Wu J, Busse D, Gómez-Mantilla JD, Stopfer P, Ince I, Huang F

31.07.26

Strategies for Successful Application of QSP Platform Models for Clinical Development and Regulatory Engagement

MIDD

QSP

Program strategies and efficiencies

Regulatory interactions

Quant Med. 2026 Jul 31;1(3):125-132.

Wang W, Chang S, Tao M, Ratushny AV, Rao R, Hosseini I, Shtylla B, Macias WL, Jin J, Cucurull-Sanchez L, Zaph S, Schmidt BJ

30.07.26

Population pharmacokinetics and pharmacodynamics of depemokimab in people with asthma and chronic rhinosinusitis with nasal polyps

MIDD

Pharmacometrics

Regulatory interactions

Trial design and analysis

Respiratory

Phase I

Phase III

J Clin Pharmacol. 2026 Aug;66(8):e70187.

Thorsted A, Tanneau L, Lavalley-Morelle A, Follows R, Jacques L, Bird N, Gevaert P, Pavord I, Ribbing J, Gupta A, Howarth P, Schalkwijk S

21.07.26

Model-based Analysis with Mechanistic Insights to CAR-T Cell Therapy Kinetics: Case Study with Axicabtagene Ciloleucel and Brexucabtagene Autoleucel

Pharmacometrics

MIDD

Methodology

Program strategies and efficiencies

Oncology

Clin Pharmacol Ther. 2026 Jul 21:10.1002/cpt.70395

Mc Laughlin AM, Bergstrand M, Ruiz-Garcia A, Filosto S, Shen R

15.07.26

Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling

PBPK & PBBM

Regulatory interactions

CPT: Pharmacometrics & Systems Pharmacology, 2026 July; 15(7)

Chenel M, Dallmann A, Ince I, Meyer M, Schlender JF, Teutonico D, Sjögren E.

25.06.26

Accelerating subcutaneous drug development: A mechanistic absorption model for the Open Systems Pharmacology framework

PBPK & PBBM

Methodology

CPT Pharmacometrics Syst Pharmacol. 2026 Jul;15(7):e70292.

Pellowe M, Dubbelboer I, Sjögren E.

04.06.26

Model-integrated evidence: A vision to expand the role of modeling in drug development and regulatory decision-making

PBPK & PBBM

MIDD

QSP

Regulatory interactions

Pharmacometrics

Program strategies and efficiencies

Quant Med. 2026;1(1). Online ahead of print.

Zhao L, Mondick J, Barrett J, Bhattacharya S, Chenel M, Corrigan B, Dutta S, Gao W, Gao X, Girish S, Hooker AC, Jones H, Langevin B, Peck C, Rostami-Hodjegan A, Sun YN, Lovern M.

04.06.26

Large Language Model-Supported Data Collation: Addressing Accuracy and Reproducibility

Immunology

Automation

Methodology

Quant Med. 2026;1(1):16-26. Online ahead of print.

Sellén S, Sjögren E

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