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Publications

Below we provide links to posters, white papers and scientific publications by Pharmetheus affiliates in chronological order. Please note that access to some publications may require a subscription.

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Publications

02.06.26

Food effect prediction of high permeability/low solubility, formulated as an amorphous solid dispersion (ASD) using an open systems pharmacology (OSP) PBBM approach

Phase I

PBPK & PBBM

Pharmacometrics

PAGE 34 (2026) Abstr 12084

Vrenken P, Lambert M, Mezzalana E, Eriksson J, Fouliard S, Sjögren E

02.06.26

Apparent time dependence and rethinking random effect under single time-to-event models

Trial design and analysis

Pharmacometrics

Methodology

PAGE 34 (2026) Abstr 12111

Bergstrand M, Friberg LE, Man P, Liu H

02.06.26

Direct and hybrid machine learning approaches do not outperform NLME-based full Bayesian forecasting for early identification of delayed methotrexate elimination

Oncology

Pharmacometrics

Methodology

PAGE 34 (2026) Abstr 11877

Klose M, Marschner D, Knott M, Wendler J, Müller-Kühnle J, Kovar L, Nyhoegen C, Hartung N, Huisinga W, Michelet R, Mc Laughlin AM, Illerhaus G, Kloft C

02.06.26

Use AUC and discard Cmax in exposure-response analyses: a global sensitivity and stochastic simulation-estimation study

Trial design and analysis

Pharmacometrics

Methodology

PAGE 34 (2026) Abstr 12278

Brekkan A, Le Louedec F, Bergstrand M, Jonsson EN

02.06.26

A mechanism-based parsimonious CAR-T cell population PK model and its validation via extension to a population PK-tumor size dynamics model: case study with axicabtagene ciloleucel and brexucabtagene autoleucel

Oncology

MIDD

Immunology

Pharmacometrics

PAGE 34 (2026) Abstr 12225

Mc Laughlin AM, Bergstrand M, Kanska J, Ruiz-Garcia A, Filosto S, Shen R

02.06.26

The use of full random effect models (FREM) in model informed precision dosing (MIPD) for a priori dose predictions

Pharmacometrics

Methodology

PAGE 34 (2026) Abstr 12244

Dimitriou M, Jönsson S, Nyberg J, Jonsson EN

02.06.26

Visual predictive checks for real-world data using propensity-score-matching

Trial design and analysis

Pharmacometrics

Methodology

PAGE 34 (2026) Abstr 12128

Keizer RJ, Bergstrand M, Hughes JH

02.06.26

Model-informed fixed dosing of rozanolixizumab in gMG: PK/PD advantages and comparison with other FcRn blockers

MIDD

Immunology

Pharmacometrics

CNS

PAGE 34 (2026) Abstr 11854

Lledó-García R, Björnsson MA

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