PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space CPT Pharmacometrics Syst Pharmacol. 2024 Sep 16. Cloesmeijer ME, Sjögren E, Koopman SF, Lenting PJ, Cnossen MH, Mathôt RAA, OPTI‐CLOT study group and SYMPHONY consortium. HematologyJournalPBPK/PBBM Pharmetheus Affiliates Principal Consultant, PBPK & PBBM Platform Scientific Lead Erik Sjögren See bio