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Below we provide links to posters, white papers and scientific publications by Pharmetheus affiliates in chronological order. Please note that access to some publications may require a subscription.

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25.06.24

A circular PK/PD/PK model explains the exposure of bulevirtide and bile salts in adult patients with Hepatitis D

Phase III

MIDD

Infectious Diseases

Program strategies and efficiencies

PAGE 32 (2024) Abstr 10978

Velez de Mendizabal N, Mc Laughlin AM, Kumar P

10.05.24

Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia

PBPK & PBBM

Infectious Diseases

J Antimicrob Chemother. 2024 Jul 1;79(7):1547-1554.

Palić S, Chu WY, Sundar S, Mondal D, Das P, Pandey K, Raja S, Rijal S, Roseboom IC, Hamadeh A, Malik PRV, Beijnen JH, Huitema ADR, Sjögren E, Alves F, Dorlo TPC.

02.04.24

Covariate modeling in pharmacometrics: General points for consideration

Trial design and analysis

Regulatory interactions

Specific populations

Pharmacometrics

CPT Pharmacometrics Syst Pharmacol . 2024 May;13(5):710-728.

Sanghavi K, Ribbing J, Rogers JA, Ahmed MA, Karlsson MO, Holford N, Chasseloup E, Ahamadi M, Kowalski KG, Cole S, Kerwash E, Wade JR, Liu C, Wang Y, Trame MN, Zhu H, Wilkins JJ

15.03.24

Bioavailability of three novel oral, sustained-release pellets, relative to an immediate-release tablet containing 500 mg flucytosine: A randomized, open-label, crossover study in healthy volunteers

PBPK & PBBM

Infectious Diseases

Clin Transl Sci. 2024 Mar;17(3):e13756

Goyal V, Krantz E, Simon F, Neven A, Eriksson J, Saayman A, Lassout NIZ, Louis M, Robinson S, Deshmukh A, Antarkar A, Ruffell C, Victor S, Chenel M, Celebic A, Caplain H, Gillon JY, Ribeiro I

28.02.24

Using forest plots to interpret covariate effects in pharmacometric models

Pharmacometrics

Methodology

CPT Pharmacometrics Syst Pharmacol. 2024 May;13(5):743-758.

Jonsson EN, Nyberg J

10.01.24

Pharmacokinetic-pharmacodynamic analysis of drug liking blockade by buprenorphine subcutaneous depot (CAM2038) in participants with opioid use disorder

Pharmacometrics

CNS

Neuropsychopharmacology. 2024 May;49(6):1050-1057.

Walsh SL, Comer SD, Zdovc JA, Sarr C, Björnsson MA, Strandgården K, Hjelmström P, Tiberg F.

21.12.23

Properties of the full random-effect modeling approach with missing covariate data

Pharmacometrics

Methodology

Stat Med. 2024 Feb 28;43(5):935-952

Nyberg J, Jonsson EN, Karlsson MO, Häggström J

07.11.23

Predicting disease effect on the pharmacokinetics (PK) of sustained and immediate release formulations by applying physiologically based pharmacokinetic (PBPK) modelling

EDCPT 2023. Poster PA-298 p.98

Eriksson J, Sjögren E, Gillon J-Y, Goyal V, Satam V, Robinson S, Caplain H, Ribeiro I, Chenel M

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