Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia

Infectious diseasesJournalPBPK-QSP

We would like to highlight important work for the treatment of post-kala-azar dermal leishmaniasis.

“The study provides the first accurate measurements of miltefosine penetration into the skin, demonstrating substantial exposure and prolonged retention of miltefosine within the skin. These findings support the use of miltefosine in cutaneous manifestations of leishmaniasis.”