Development of a Physiologically-Based Pharmacokinetic Model for Coproporphyrin I (CP-I) Using the Open Systems Pharmacology Software Suite (PK-Sim and MoBi) for assessment of OATP1B-based DDIs

PBPK & PBBM

Methodology

Kanacher T, Pellowe M, Kovar C, Eriksson J, Huang F, Wu F, Sailer R, Busse D, Gómez-Mantilla JD