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Jurgen Langenhorst

Jurgen Langenhorst

Jurgen Langenhorst, Ph.D.

Senior Director, MIDD Consultant

Joined Pharmetheus in 2019, actively working in client projects and serving as Project Portfolio Team Leader
Expertise includes item-response theory, pediatrics, QTc analysis, and clinical pharmacology in therapeutic areas such as immunology and oncology
Previously worked as Production Pharmacist at the University Medical Center Utrecht, the Netherlands, where he supported daily practice in the manufacturing department of the pharmacy
M.Sc. in Pharmacy (2015) from Utrecht University, the Netherlands, and Ph.D. in Pharmaceutics (2019) from the University Medical Centre Utrecht, the Netherlands

Pharmetheus affiliated publications

Risks encountered when not adjusting for diurnal variation and food effect in QTcF analysis based on Phase I data Application of model-informed drug development for dose optimization of brigimadlin in patients with dedifferentiated liposarcoma Using Full Random Effects Models (FREM) in different software A novel model for Platelets Dynamics: a pragmatic systems approach to characterize thrombocytopenia across multiple compounds and drug classes A disease model predicting placebo response and remission status of patients with ulcerative colitis using modified Mayo score Concentration QTc Analysis of Giredestrant: Overcoming QT/heart rate Confounding in the Presence of Drug-Induced Heart Rate Changes An Item Response Theory Model with Bounded Integer Subcomponents to Describe the Mayo Clinic Subscores in Patients with Ulcerative Colitis [2] An item response theory model with bounded integer subcomponents to describe the Mayo Clinic subscores in patients with ulcerative colitis How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example Clinical Trial Simulation To Optimize Trial Design for Fludarabine Dosing Strategies in Allogeneic Hematopoietic Cell Transplantation A Semi-Mechanistic Model Based on Glutathione Depletion to Describe Intra-Individual Reduction in Busulfan Clearance

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Kungsängstull 4  
753 19 Uppsala, Sweden

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Dragarbrunnsgatan 77, 5th floor

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Pharmetheus is a consultancy firm helping clients reduce uncertainty in technical and regulatory processes, increasing confidence in the development of new medicines that can improve patients’ lives.

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