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A Semi-Mechanistic Model Based on Glutathione Depletion to Describe Intra-Individual Reduction in Busulfan Clearance

Br J Clin Pharmacol. 2020 Aug;86(8):1499-1509.
Langenhorst J, Boss J, van Kesteren C, Lalmohamed A, Kuball J, Egberts ACG, Boelens JJ, Huitema ADR, van Maarseveen EM.
HematologyJournalOncologyPharmacometrics

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Portrait-of-Jurgen-Langenhorst_Pharmetheus
Senior Director, MIDD Consultant

Jurgen Langenhorst

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Pharmetheus is a consultancy firm helping clients reduce uncertainty in technical and regulatory processes, increasing confidence in the development of new medicines that can improve patients’ lives.