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Publications

Below we provide links to posters, white papers and scientific publications by Pharmetheus affiliates in chronological order. Please note that access to some publications may require a subscription.

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Publications

01.06.22

Anticoagulant Effects of Dabigatran on Coagulation Laboratory Parameters in Pediatric Patients: Combined Data from Five Pediatric Clinical Trials

Specific populations

Pharmacometrics

Hematology

Thromb Haemost. 2022 Sep;122(9):1573-1583

Mitchell LG, Röshammar D, Huang F, Albisetti M, Brandão LR, Bomgaars L, Chalmers E, Halton J, Luciani M, Joseph D, Tartakovsky I

01.06.22

How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example

MIDD

Cardiovascular

Regulatory interactions

Pharmacometrics

Program strategies and efficiencies

Clin Pharmacol Ther. 2023 Feb;113(2):310-320

Meyer C, Dierick I, Gauderat G, Langenhorst J, Sarr C, Leroux E, Chenel M, Fouliard S, Passier P

01.06.22

Population Pharmacokinetics and Exposure-Response Relationships of Astegolimab in Patients with Severe Asthma

Pharmacometrics

Respiratory

J Clin Pharmacol. 2022 Jul;62(7):905-917.

Kotani N, Dolton M, Svensson RJ, Ribbing J, Friberg LE, Vadhavkar S, Cheung D, Staton T, Sperinde G, Jin J, Putnam WS, Quartino A

01.05.22

A Quantitative Approach to the Choice of Number of Samples for Percentile Estimation in Bootstrap and Visual Predictive Check Analyses

Pharmacometrics

CPT Pharmacometrics Syst Pharmacol. 2022 Jun;11(6):673-686.

Jonsson EN, Nyberg J

01.04.22

Physiological Based Pharmacokinetic and Biopharmaceutics Modelling of Subcutaneously Administered Compounds – An Overview of In Silico Models

PBPK & PBBM

Program strategies and efficiencies

Int J Pharm. 2022 Jun 10;621:121808.

Dubbelboer IR, Sjögren E

30.03.22

Overview of Authorized Drug Products for Subcutaneous Administration: Pharmaceutical, Therapeutic, and Physicochemical Properties

Program strategies and efficiencies

Eur J Pharm Sci. 2022 Jun 1;173:106181.

Dubbelboer IR, Sjögren E

01.03.22

Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia

Oncology

MIDD

Pharmacometrics

Hematology

Cancer Research Communications. 2022 Nov;2(11):1532-44.

Derippe T, Fouliard S, Marchiq I, Dupouy S, Almena-Carrasco M, Geronimi J, Declèves X, Chenel M, Mager DE

03.02.22

Caplacizumab Model-Based Dosing Recommendations in Pediatric Patients With Acquired Thrombotic Thrombocytopenic Purpura [2]

MIDD

Specific populations

Pharmacometrics

Hematology

J Clin Pharmacol. 2022 Mar;62(3):409-421.

Bergstrand M, Hansson E, Delaey B, Callewaert F, Sousa RP, Sargentini-Maier ML

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