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Publications

Below we provide links to posters, white papers and scientific publications by Pharmetheus affiliates in chronological order. Please note that access to some publications may require a subscription.

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Publications

05.11.21

Investigating the Identifiability of One-Stage IVIVC Population Models for Extended-Release Dosage Forms

Trial design and analysis

Pharmacometrics

PAGE 29 (2021) Abstr 9691.

Zannoni S, Brekkan A, Smania G

01.11.21

Effect of Ponesimod Exposure on Total Lymphocyte Dynamics in Patients with Multiple Sclerosis

Pharmacometrics

CNS

Clin Pharmacokinet. 2021 Sep:60(9):1239-1250.

Valenzuela B, Pérez-Ruixo JJ, Leirens Q, Ouwerkerk-Mahadevan S, Poggesi I

01.11.21

Modeling Restoration of Gefitinib Efficacy by Co-Administration of MET Inhibitors in an EGFR Inhibitor-Resistant NSCLC Xenograft Model: A Tumor-in-Host DEB-Based Approach

Oncology

MIDD

Pharmacometrics

CPT Pharmacometrics Syst Pharmacol. 2021 Nov;10(11):1396-1411.

Tosca EM, Gauderat G, Fouliard S, Burbridge M, Chenel M, Magni P

01.10.21

Population Repeated Time-to-Event Analysis of Exacerbations in Asthma Patients: A Novel Approach for Predicting Asthma Exacerbations Based on Biomarkers, Spirometry, and Diaries/Questionnaires

MIDD

Pharmacometrics

Respiratory

CPT Pharmacometrics Syst Pharmacol. 2021 Oct;10(10):1221-1235.

Svensson RJ, Ribbing J, Kotani N, Dolton M, Vadhavkar S, Cheung D, Staton T, Choy DF, Putnam W, Jin J, Budha N, Karlsson MO, Quartino A, Zhu R

06.09.21

The Population PKPD of Unacylated and Acylated Ghrelin Following Single Rising Doses of BI 1356225 in Healthy Subjects is Impacted by the Time Since Last Meal

Endocrinology

Pharmacometrics

Metabolism

PAGE 29 (2021) Abstr 9806.

Svensson RJ, Henrich A, Bianzano S, Sarubbi D, Röshammar D, Beetz N

06.09.21

Caplacizumab Model-Based Dosing Recommendations In Pediatric Patients With Acquired Thrombotic Thrombocytopenic Purpura

MIDD

Specific populations

Pharmacometrics

Hematology

PAGE 29 (2021) Abstr 9653.

Sou T, Hansson E, Bergstrand M, Callewaert F, Sousa RP, Sargentini L

06.09.21

Conditional Distribution Modeling for Covariates Simulation Using Classification and Regression Trees Methods

Trial design and analysis

Specific populations

Pharmacometrics

PAGE 29 (2021) Abstr 9632.

Smania G, Jonsson EN

06.09.21

Conditional Distribution Modeling as an Alternative Method for Covariates Simulation: Comparison with Joint Multivariate Normal and Bootstrap Techniques

Trial design and analysis

Specific populations

Pharmacometrics

CPT Pharmacometrics Syst Pharmacol. 2021 Apr;10(4):330-9.

Smania G, Jonsson EN

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