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  1. Home
  2. Publications

Publications

Below we provide links to posters, white papers and scientific publications by Pharmetheus affiliates in chronological order. Please note that access to some publications may require a subscription.

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Publications

01.11.17

Exposure-Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients With Prior Myocardial Infarction

MIDD

Cardiovascular

Trial design and analysis

Pharmacometrics

Hematology

J Clin Pharmacol. 2017 May;57(5):573-583.

Röshammar D, Nyberg J, Andersson T, Stanski D, Storey RF, Hamrén B

08.07.17

Population Pharmacokinetics of Ticagrelor and AR-C124910XX in Patients with Prior Myocardial Infarction

Cardiovascular

Pharmacometrics

Hematology

Int J Clin Pharmacol Ther. 2017 May;55(5):416-424.

Röshammar D, Bergstrand M, Andersson T, Storey RF, Hamrén B

06.06.17

Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics

CPT Pharmacometrics Syst Pharmacol. 2017 Feb;6(2):87-109.

Nguyen THT, Mouksassi M-S, Holford N, Al-Huniti N, Freedman I, Hooker AC, John J, Karlsson MO, Mould DR, Pérez-Ruixo JJ, Plan EL, Savic R, van Hasselt JGC, Weber B, Zhou C, Comets E, Mentré F, for the Model Evaluation Group of the International Society of Pharmacometrics (ISoP) Best Practice Committee

06.06.17

Dosing and Switching Strategies for Paliperidone Palmitate 3-Month Formulation in Patients with Schizophrenia Based on Population Pharmacokinetic Modeling and Simulation, and Clinical Trial Data

Trial design and analysis

Specific populations

Pharmacometrics

CNS

CNS Drugs. 2017 Apr;31(4):273-288.

Magnusson MO, Samtani MN, Plan EL, Jonsson EN, Rossenu S, Vermeulen A, Russu A

02.05.17

Population Pharmacokinetics of a Novel Once-Every 3 Months Intramuscular Formulation of Paliperidone Palmitate in Patients with Schizophrenia

Pharmacometrics

CNS

Clin Pharmacokinet. 2017 Apr;56(4):421-433.

Magnusson MO, Samtani MN, Plan EL, Jonsson EN, Rossenu S, Vermeulen A, Russu A

01.05.17

Pharmacokinetic and Exposure-Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients with Prior Myocardial Infarction (PEGASUS-TIMI 54)

Cardiovascular

Trial design and analysis

Pharmacometrics

Hematology

PAGE 26 (2017) Abstr 7264.

Hamrén B, Röshammar D, Nyberg J, Bergstrand M, Andersson T, Storey RF, Stanski D

01.04.17

A Regulatory View on Dose Finding Studies and on the Value of Dose-Exposure-Response Analysis

MIDD

Regulatory interactions

Program strategies and efficiencies

In O’Quigley J, Iasonos A, Bornkamp B, (Eds), Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials. Boca Raton FL:CRC Press.

Friberg Hietala S, Manolis E, Musuamba FT

01.04.17

An Automated Sampling Importance Resampling Procedure for Estimating Parameter Uncertainty [2]

J Pharmacokinet Pharmacodyn. 2017 Dec;44(6):509-520.

Dosne AG, Bergstrand M, Karlsson MO

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Pharmetheus is a consultancy firm helping clients reduce uncertainty in technical and regulatory processes, increasing confidence in the development of new medicines that can improve patients’ lives.

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