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Below we provide links to posters, white papers and scientific publications by Pharmetheus affiliates in chronological order. Please note that access to some publications may require a subscription.

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03.06.25

A Bayesian-NLME approach identifies patients at risk of delayed MTX elimination if informative TDM data is provided

Oncology

Trial design and analysis

Pharmacometrics

Methodology

PAGE 33 (2025) Abstr 11507

Klose M, Marschner D, Knott M, Wendler J, Müller-Kühnle J, Kovar L, Huisinga W, Nyhoegen C, Michelet R, Mc Laughlin AM, Illerhaus G, Kloft C.

03.06.25

Population pharmacokinetic analysis of doxecitine and doxribtimine in patients with thymidine kinase 2 deficiency and in healthy volunteers

Phase II

Regulatory interactions

Pharmacometrics

Genetic

PAGE 33 (2025) Abstr 11353

Bouchene S, Mittur A, Naik H, Dua P, Neldemo I, Ribbing J, Bergstrand M, Khandelwal A.

03.06.25

Exposure-response analysis for time-to-event data in the presence of adaptive dosing: efficient approaches and pitfalls (Poster)

MIDD

Trial design and analysis

Methodology

PAGE 33 (2025) Abstr 11525

Lavalley-Morelle A, Le Louedec F, Anziano R, Mentré F, Bergstrand M

02.06.25

Predicting atorvastatin acid pharmacokinetics in a complex enzyme- and transporter-mediated drug–drug interaction network using physiologically based pharmacokinetic modeling

PBPK & PBBM

Cardiovascular

DDI Workshop, Marbach 2025

Kovar C, Kanacher T, Huang F, Wu J, Sailer R, Busse D, Gómez-Mantilla JD, Ince I.

29.05.25

Modernizing Preclinical Drug Development: The Role of New Approach Methodologies

Phase I

MIDD

QSP

Preclinical

Regulatory interactions

ACS Pharmacol. Transl. Sci. 2025, 8, 6, 1513–1525

Mehta K, Maass C, Cucurull-Sanchez L, Pichardo-Almarza C, Subramanian K, Androulakis IP, Gobburu J, Schaller S, Sherwin CM

25.05.25

Population pharmacokinetic analysis of an octreotide depot (CAM2029) in the treatment of acromegaly

MIDD

Endocrinology

Pharmacometrics

Genetic

Clin Pharmacokinet. 2025 Jul;64(7):1079-1092. Online ahead of print.

Glatard A, Friberg-Hietala S, Keutzer L, Hansson A, Johnsson M, Tiberg F.

22.05.25

Population Pharmacokinetics and Exposure–Response Relationships of Etrolizumab in Patients with Moderately-to-Severely Active Crohn's Disease

MIDD

Regulatory interactions

Pharmacometrics

Gastroenterology

J Clin Pharmacol. 2025 May 22. Online ahead of print.

Moein A, Ribbing J, Ibrahim MMA, Zhang W, Kassir N

07.05.25

A mathematical viral load model characterises the exposure- response relationship between bulevirtide and hepatitis delta virus and identifies the minimum duration of on-treatment viral load monitoring required for accurate prediction of long-term virologic response

Trial design and analysis

Pharmacometrics

Infectious Diseases

Program strategies and efficiencies

J. Hepatol. 82:S822-S823

Kumar P, Mc Laughlin AM, Velez de Mendizabal N, Caro L, Damoiseaux D, Lichtman A, Manuilov D, Mercier R, Ni L, Liu Y, Mo H, Ruiz-Garcia A

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