Open source PBPK modeling with the OSPSuite for MIDD

Interested in PBPK? Join this one-day online* workshop held on 28th March 2022, in connection with WCoP, led by Pharmetheus' PBPK experts.

Workshop overview

The workshop will feature PBPK modelling with the Open Systems Pharmacology suite (OSPS) also known as PK-Sim® and MoBi®. 

The goals are:

  • Getting an introduction to the open source PBPK software PK-Sim® & MoBi® and it’s use for small molecule for investigations in clinical drug development.
  • Learn how to do age dependent extrapolation with PBPK models (very young or very old populations).
  • Learn how to model complex DDIs

The combination of use cases based on published examples and hands-on lectures will enable the participants to build their own PBPK projects and maximise their impact by integrating physiological and mechanistic knowledge with preclinical and clinical information. While the workshop is aimed for beginners with PK-Sim® & MoBi®, many topics will be of interest even for advanced users.

Workshop learning objectives

During the workshop, the participants will have the opportunity to become familiar with the software in extensive hands-on sessions, which will follow a brief introduction to the basic concepts of PBPK. The participants will have a chance to experience the stepwise PBPK model development and qualification. 


First, a base PBPK model is built and compared to observed data. Then the model is refined and through a question-based approach strategy further aspects for model extrapolation are explored. 


Next, the use of PBPK modelling for development of a DDI strategy is shown. We will teach you how to use and integrate preexisting models and building blocks to create a whole-body PBPK model for complex DDIs (e.g. simultaneous induction and inhibition by a perpetrator) and optimise study protocols. 


Finally, a workflow is presented on how PBPK models can extrapolate beyond tested scenarios like scaling form adult populations to young, old and very old.

Workshop target audience

Scientists/Pharmacometricians interested in physiologically based pharmacokinetic modeling (PBPK) modelling and interested in learning how to consider age dependency, predict drug-drug interactions (DDIs) and conduct population simulations in PK-Sim® & MoBi®.


Participants are expected to use their laptops and have installed the OSPSuite packages on their laptops (for instructions and software please visit

For starters it is useful to check out the tutorial site (videos & hands-on) here:

Workshop faculty

Erik Sjögren

Erik Sjögren, Assoc. Prof, Ph.D.

Senior Consultant at Pharmetheus

Tobias Kanacher

Tobias Kanacher

Senior Consultant at Pharmetheus

*This workshop is going to be held either as hybrid or fully virtual, i.e. online attendance possible in either options, and face-to-face
attendance facilitated depending on the sanitary situation evolution and organizing committee decisions.

This one-day workshop is sponsored by Pharmetheus and co-hosted by Pharmacometrics Africa, NPC

PBPK-QSP at Pharmetheus​

Our PBPK-QSP team generates up-to-date content compatible with the global regulatory environment, scientific advancements and the needs of the pharmaceutical industry. We offer PBPK-QSP analyses primarily using the open source software tools PK-Sim® and MoBi®, and we are active members of the Open Systems Pharmacology Management Team.