Our Publications

Below we provide links to posters and publications by Pharmetheus affiliates in chronological order.
Please note that access to some publications may require a subscription.

2021

Bergstrand M, Hansson E, Delaey B, Callewaert F, De Passos Sousa R, Sargentini‐Maier ML.

Modeling and simulation support for regulatory approvals of caplacizumab

Pharmetheus Affiliates

Tosca EM, Gauderat G, Fouliard S, Burbridge M, Chenel M, Magni P.

Modeling restoration of gefitinib efficacy by co-administration of MET inhibitors in an EGFR inhibitor-resistant NSCLC xenograft model: A tumor-in-host DEB-based approach

Pharmetheus Affiliates

Svensson RJ, Ribbing J, Kotani N, Dolton M, Vadhavkar S, Cheung D, Staton T, Choy DF, Putnam W, Jin J, Budha N, Karlsson MO, Quartino A, Zhu R.

Population repeated time-to-event analysis of exacerbations in asthma patients: A novel approach for predicting asthma exacerbations based on biomarkers, spirometry, and diaries/questionnaires

Pharmetheus Affiliates

Schmid U, Weber B, Sarr C, Freiwald M.

Exposure–safety analyses of nintedanib in patients with chronic fibrosing interstitial lung disease

Pharmetheus Affiliates

Valenzuela B, Pérez-Ruixo JJ, Leirens Q, Ouwerkerk-Mahadevan S, Poggesi I

Effect of Ponesimod Exposure on Total Lymphocyte Dynamics in Patients with Multiple Sclerosis

Pharmetheus Affiliates

Smania G, Jonsson EN

Conditional distribution modeling as an alternative method for covariates simulation: comparison with joint multivariate normal and bootstrap techniques

Pharmetheus Affiliates

Schmid U, Weber B, Magnusson MO, Freiwald M

Exposure-Efficacy Analyses of Nintedanib in Patients with Chronic Fibrosing Interstitial Lung Disease

Pharmetheus Affiliates

Röshammar D, Huang F, Albisetti M, Bomgaars L, Chalmers E, Luciani M, Halton J, Mitchell LG, Bergstrand M, Ibrahim MMA, Joseph D, Tartakovsky I, Gropper S, Brueckmann M, Brandão LR.

Pharmacokinetic Modeling and Simulation Support for Age‐ and Weight‐Adjusted Dosing of Dabigatran Etexilate in Children with Venous Thromboembolism

Pharmetheus Affiliates

Sjögren E, Tarning J, Barnes KI, Jonsson EN

A Physiologically-Based Pharmacokinetic Framework for Prediction of Drug Exposure in Malnourished Children

Pharmetheus Affiliates

2020

Kanacher T, Lindauer A, Mezzalana E, Michon I, Veau C, Mantilla JD, Nock V, Fleury A

A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug-Drug-Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine

Pharmetheus Affiliates

No data was found

Svensson RJ, Ribbing J, Kotani N, Dolton M, Vadhavkar S, Cheung D, Staton T, Choy DF, Putnam W, Jin J, Budha N, Karlsson MO, Quartino A, Zhu R.

Population RTTE analysis of exacerbations in asthma patients: a novel approach for predicting asthma exacerbations based on biomarkers, spirometry and diaries/questionnaires

Pharmetheus Affiliates

Roeshammar D, Huang F, Albisetti M, Bomgaars L, Chalmers E, Luciani M, Halton J, Mitchell L, Joseph D, Tartakovsky I, Gropper S, Reilly P, Brueckmann M, Brandão L, on Behalf of the Study Investigators .

Pharmacokinetic Modelling and Simulation Support the Age and Body-Weight-Adjusted Dosing of Dabigatran Etexilate in Paediatric Patients with Venous Thromboembolism

Pharmetheus Affiliates

Anziano RJ, Milligan P

Model Informed Drug Development: Collaboration Through A Common Framework

Pharmetheus Affiliates

Mitra A, Suarez-Sharp S, Pepin XJH, Flanagan T, Zhao Y, Kotzagiorgis E, Parrott N, Sharan S, Tistaert C, Heimbach T, Zolnik B, Sjögren E, Wu F, Anand O, Kakar S, Li M, Veerasingham S, Kijima S, Lima Santos GM, Ning B, Raines K, Rullo G, Mandula H, Delvadia P, Dressman J, Dickinson PA, Babiskin A.

Applications of Physiologically Based Biopharmaceutics Modeling (PBBM) to Support Drug Product Quality: A Workshop Summary Report

Pharmetheus Affiliates

Pepin X, Dressman J, Parrott N, Delvadia P, Mitra A, Zhang X, Babiskin A Kolhatkar V Seo P Taylor L Sjögren E Butler J Kostewicz E Tannergren C Koziolek M Kesisoglou F Dallmann A Zhao Y Suarez-Sharp S

In Vitro Biopredictive Methods: A Workshop Summary Report

Pharmetheus Affiliates

2019

Lippert J, Burghaus R, Edginton A, Frechen S, Karlsson M, Kovar A, Lehr T, Milligan P, Nock V, Ramusovic S, Riggs M, Schaller S, Schlender J, Schmidt S, Sevestre M, Sjögren E, Solodenko J, Staab A, Teutonico D

Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Pharmetheus Affiliates

Schoemaker R, Nayak S, Harnisch LO, Karlsson MO; VISTA-ICH Collaboration

Modeling and simulation of the modified Rankin Scale and National Institutes of Health Stroke Scale neurological endpoints in intracerebral hemorrhage

Pharmetheus Affiliates

Sargentini L, Hansson E, Bergstrand M, Callewaert F, Sousa R.

Effect of plasma exchange on the pharmacokinetics and pharmacodynamics of Caplacizumab, PS1487

Pharmetheus Affiliates

Sargentini L, Hansson E, Bergstrand M, Callewaert F, Sousa R.

Caplacizumab model-based dosing recommendations in pediatric patients with acquired thrombotic thrombocytopenic purpura, PB2249

Pharmetheus Affiliates

Brekkan A, Lopez-Lazaro L, Plan EL, Nyberg J, Kankanwadi S, Karlsson MO

Sensitivity of Pegfilgrastim Pharmacokinetic and Pharmacodynamic Parameters to Product Differences in Similarity Studies

Pharmetheus Affiliates

Bergstrand M, Hansson E, Sargentini-Maier L

Caplacizumab Dosing Rational in aTTP Patients Supported by Mechanism Based PKPD Modelling

Pharmetheus Affiliates

Kristoffersson A, Röshammar D, Plan EL

Assessment of expected drug exposure relative maximum safety limits in early phase studies

Pharmetheus Affiliates

Brekkan A, Lopez-Lazaro L, Plan EL, Acharya C, Yngman G, Nyberg J, Hooker AC, Kankanwadi S, Karlsson MO

Model based support to biosimilarity assessment planning – A case study of pegfilgrastim

Pharmetheus Affiliates

Nyberg J, Karlsson MO, Jonsson EN

Implicit and efficient handling of missing covariate information using full random effects modelling

Pharmetheus Affiliates

Sjögren E, Jonsson EN

A PBPK Framework to Predict Drug Exposure in Malnourished Children

Pharmetheus Affiliates

Sarr C, Magnusson MO, Vajjah P, Zamacona M

Population PK and PASI exposure-response modelling for Certolizumab pegol in patients with chronic plaque psoriasis

Pharmetheus Affiliates

Nyberg J, Jonsson EN, Karlsson MO, Häggström J, members of the HBGDki Community

Properties of the full random effect modelling approach with missing covariates

Pharmetheus Affiliates

Heimbach T, Suarez-Sharp S, Kakhi M, Holmstock N, Olivares-Morales A, Pepin X, Sjögren E, Tsakalozou E, Seo P, Li M, Zhang X, Lin HP, Montague T, Mitra A, Morris D, Patel N, Kesisoglou F

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link-a Workshop Summary Report

Pharmetheus Affiliates

Netterberg I, Li CC, Molinero L, Budha N, Sukumaran S, Stroh M, Jonsson EN, Friberg LE

A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab-Treated non-small Cell Lung Cancer Patients

Pharmetheus Affiliates

2018

Guiastrennec B, Sonne DP, Bergstrand M, Vilsbøll T, Knop FK, Karlsson MO

Model-Based Prediction of Plasma Concentration and Enterohepatic Circulation of Total Bile Acids in Humans

Pharmetheus Affiliates

Suarez-Sharp S, Cohen M, Kesisoglou F, Abend A, Marroum P, Delvadia P, Kotzagiorgis E, Li M, Nordmark A, Bandi N, Sjögren E, Babiskin A, Heimbach T, Kijima S, Mandula H, Raines K, Seo P, Zhang X

Applications of Clinically Relevant Dissolution Testing: Workshop Summary Report

Pharmetheus Affiliates

Brekkan A, Lopez-Lazaro L, Yngman G, Plan EL, Acharya C, Hooker AC, Kankanwadi S, Karlsson MO

A Population Pharmacokinetic-Pharmacodynamic Model of Pegfilgrastim

Pharmetheus Affiliates

Jonsson EN, Harling K

Increasing the efficiency of the covariate search algorithm in the SCM

Pharmetheus Affiliates

Kantasiripitak W, Sjögren E, Magnusson MO

Bridging physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) analyses in paediatric drug development: A case study based on intravenous esomeprazole

Pharmetheus Affiliates

Rasmussen CH, Smith MK, Ito K, Sundararajan V, Magnusson MO, Jonsson NE, Fostvedt L, Burger P, McFadyen L, Tensfeldt TG, Nicholas T

PharmTeX: a LaTeX-Based Open-Source Platform for Automated Reporting Workflow

Pharmetheus Affiliates

2017

Friberg Hietala S, Manolis E, Musuamba F T

A Regulatory View on Dose Finding Studies and on the Value of Dose-Exposure-Response Analysis

In O’Quigley J., Iasonos A., Bornkamp B., (Eds.), Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials. Boca Raton FL:CRC Press

Pharmetheus Affiliates

Magnusson MO, Samtani MN, Plan EL, Jonsson EN, Rossenu S, Vermeulen A, Russu A

Dosing and Switching Strategies for Paliperidone Palmitate 3-Month ormulation in Patients with Schizophrenia Based on Population PharmacokineticModeling and Simulation, and Clinical Trial Data

Pharmetheus Affiliates

Dosne AG, Bergstrand M, Karlsson MO

An Automated Sampling Importance Resampling Procedure for Estimating Parameter Uncertainty

Pharmetheus Affiliates

Conrado DJ, Karlsson MO, Romero K, Sarr C, Wilkins JJ

Open innovation: Towards sharing of data, models and workflows

Pharmetheus Affiliates

Yngman G, Nyberg J, Jonsson EN, Karlsson MO

Practical considerations for using the full random effects modeling (FREM) approach to covariate modeling

Pharmetheus Affiliates

2016

Röshammar D, Bergstrand M, Andersson T, Storey R.F, Hamrén B

Population pharmacokinetics of ticagrelor and AR-C124910XX in patients with prior myocardial infarction

Pharmetheus Affiliates

Slejko JF, Willke RJ, Ribbing J, Milligan P

Translating Pharmacometrics to a Pharmacoeconomic Model of COPD

Pharmetheus Affiliates

Röshammar D, Nyberg J, Andersson T, Stanski D, Storey RF, Hamrén B

Exposure-Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients With Prior Myocardial Infarction

Pharmetheus Affiliates

Nguyen T, Mouksassi M-S, Holford N, Al-Huniti N, Freedman I, Hooker AC, John J, Karlsson M, Mould D, Pérez Ruixo J, Plan EL, Savic R, van Hasselt J, Weber B, Zhou C, Comets E, Mentré F for the Model Evaluation Group of the International Society of Pharmacometrics (ISoP)

Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics

Pharmetheus Affiliates

Magnusson MO, Samtani MN, Plan EL, Jonsson EN, Rossenu S, Vermeulen A, Russu A

Population Pharmacokinetics of a Novel Once-Every 3 Months Intramuscular Formulation of Paliperidone Palmitate in Patients with Schizophrenia

Pharmetheus Affiliates

van Schaick E, Benninga MA, Levine A, Magnusson MO, Troy S

Development of apopulation pharmacokinetic model of prucalopride in children with functional constipation

Pharmetheus Affiliates

Magnusson MO

Application of a multi-criteria decision analysis model in the dose selection of combination therapy for overactive bladder

Pharmetheus Affiliates

Jonsson EN, Xie R, Marshall SF, Arends RH

Population pharmacokinetics of tanezumab in phase 3 clinical trials for osteoarthritis pain

Pharmetheus Affiliates

Jonsson EN, Nyberg J, Häggström J, Lifecycle Auxology & Neurocognitive Development team, representing the Healthy Birth, Growth and Development knowledge integration (HBGDki) community

Determinants for physical growth patterns in low- and middle-income countries

Pharmetheus Affiliates