Our Publications

Below we provide links to posters and publications by Pharmetheus affiliates in chronological order.
Please note that access to some publications may require a subscription.

2022

Moein A, Lu T, Jönsson S, Ribbing J, Kassir N, Zhang W, Sperinde G, Zhang R, Tang M, Oh YS, Bruno R.

Population pharmacokinetic analysis of etrolizumab in patients with moderately-to-severely active ulcerative colitis

Pharmetheus Affiliates

Mitchell LG, Röshammar D, Huang F, Albisetti M, Brandão LR, Bomgaars L, Chalmers E, Halton J, Luciani M, Joseph D, Tartakovsky I.

Anticoagulant Effects of Dabigatran on Coagulation Laboratory Parameters in Pediatric Patients: Combined Data from Five Pediatric Clinical Trials.

Pharmetheus Affiliates

Svensson RJ, Jonsson EN.

Efficient and relevant stepwise covariate model building for pharmacometrics

Pharmetheus Affiliates

Xiong W, Hietala SF, Nyberg J, Papasouliotis O, Johne A, Berghoff K, Goteti K, Dong J, Girard P, Venkatakrishnan K, Strotmann R.

Exposure–Response Analyses for the MET Inhibitor Tepotinib Including Patients in the Pivotal VISION Trial: Support for Dosage Recommendations

Pharmetheus Affiliates

Dubbelboer IR, Sjögren E.

Physiological Based Pharmacokinetic and Biopharmaceutics Modelling of Subcutaneously Administered Compounds – An Overview of In Silico Models

Pharmetheus Affiliates

Dubbelboer IR, Sjögren E.

Overview of Authorized Drug Products for Subcutaneous Administration: Pharmaceutical, Therapeutic, and Physicochemical Properties

Pharmetheus Affiliates

Jonsson EN, Nyberg J.

A Quantitative Approach to the Choice of Number of Samples for Percentile Estimation in Bootstrap and Visual Predictive Check Analyses

Pharmetheus Affiliates

Kotani N, Dolton M, Svensson RJ, Ribbing J, Friberg LE, Vadhavkar S, Cheung D, Staton T, Sperinde G, Jin J, Putnam WS, Quartino A.

Population Pharmacokinetics and Exposure-Response Relationships of Astegolimab in Patients with Severe Asthma

Pharmetheus Affiliates

Xiong W, Papasouliotis O, Jonsson EN, Strotmann R, Girard P.

Population Pharmacokinetic Analysis of Tepotinib, an Oral MET Kinase Inhibitor, Including Data From the VISION Study

Pharmetheus Affiliates

Tomita Y, Hansson E, Mazuir F, Wellhagen G, Ooi QX, Mezzalana E, Kitamura A, Nemoto D, Bolze S.

Imeglimin Population Pharmacokinetics and Dose Adjustment Predictions for Renal Impairment in Japanese and Western Patients with Type 2 Diabetes

Pharmetheus Affiliates

Meyer C, Dierick I, Gauderat G, Langenhorst J, Sarr C, Leroux E, Chenel M, Fouliard S, Passier P.

How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example

Pharmetheus Affiliates

Bergstrand M, Hansson E, Delaey B, Callewaert F, Sousa RP, Sargentini-Maier ML.

Caplacizumab Model-Based Dosing Recommendations in Pediatric Patients With Acquired Thrombotic Thrombocytopenic Purpura

Pharmetheus Affiliates

Yngman G, Bjugård Nyberg H, Nyberg J, Jonsson EN, Karlsson MO.

An Introduction to the Full Random Effects Model

Pharmetheus Affiliates

2021

Tosca EM, Gauderat G, Fouliard S, Burbridge M, Chenel M, Magni P.

Modeling Restoration of Gefitinib Efficacy by Co-Administration of MET Inhibitors in an EGFR Inhibitor-Resistant NSCLC Xenograft Model: A Tumor-in-Host DEB-Based Approach

Pharmetheus Affiliates

Moein A, Lu T, Jönsson S, Ribbing J, Kassir N, Zhang W, Zhang R, Tang M, Oh YS, Bruno R, Zhu R.

Population Pharmacokinetic Analysis of Etrolizumab in Patients with Moderately-to-Severely Active Ulcerative Colitis

Pharmetheus Affiliates

Kassir N, Zhu R, Moein A, Langenhorst J, Ribbing J, Zhang R, Tang M, Oh YS, Zhang W.

Exposure-Response Analysis of Etrolizumab in Patients with Moderately-to-severely Active Ulcerative Colitis

Pharmetheus Affiliates

Svensson RJ, Ribbing J, Kotani N, Dolton M, Vadhavkar S, Cheung D, Staton T, Choy DF, Putnam W, Jin J, Budha N, Karlsson MO, Quartino A, Zhu R.

Population Repeated Time-to-Event Analysis of Exacerbations in Asthma Patients: A Novel Approach for Predicting Asthma Exacerbations Based on Biomarkers, Spirometry, and Diaries/Questionnaires

Pharmetheus Affiliates

Faelens R, Luyckx N, Leirens Q, Bouillon T, Kuypers D, Annaert P.

Building Model-Informed Precision Dosing Software Using R: Blueprint for a State-of-the-Art Development Process

Pharmetheus Affiliates

Noack A, Mogensen PK, Nyberg J, Ivaturi V.

Generalized FOCE with Pumas

Pharmetheus Affiliates

Zannoni S, Brekkan A, Smania G.

Investigating the Identifiability of One-Stage IVIVC Population Models for Extended-Release Dosage Forms

Pharmetheus Affiliates

Mezzalana E, Tomita Y, Hansson E, Mazuir F, Wellhagen G, Ooi QX, Kitamura A, Nemoto D, Bolze S.

Population Pharmacokinetic Modelling and Simulation of Imeglimin in Type 2 Diabetes Patients to Support Dose Recommendations to Patients with Renal Impairment

Pharmetheus Affiliates

Sou T, Hansson E, Bergstrand M, Callewaert F, Sousa RP, Sargentini L.

Caplacizumab Model-Based Dosing Recommendations In Pediatric Patients With Acquired Thrombotic Thrombocytopenic Purpura

Pharmetheus Affiliates

Sjögren E, Tarning J, Jonsson EN.

Lumenfantrine Exposure in Malnourished Children: PBPK Modeling Applied for Predictions and Dose Adjustments

Pharmetheus Affiliates

Smania G, Jonsson EN.

Conditional Distribution Modeling for Covariates Simulation Using Classification and Regression Trees Methods

Pharmetheus Affiliates

Acharya C, Magnusson MO, Vajjah P, Zamacona M.

Population Pharmacokinetic and Exposure-Response Models for Dapirolizumab Pegol in Patients with Systemic Lupus Erythematosus

Pharmetheus Affiliates

Mats Magnusson

Mats Magnusson, Ph.D.

Ibrahim MMA, Plan EL, Jönsson S, Chen C, Karlsson MO.

Enhancing Efficiency and Decision Quality in Parkinson’s Disease Drug Trials for LRRK2 Programs Using Item Response Modelling

Pharmetheus Affiliates

Svensson RJ, Henrich A, Bianzano S, Sarubbi D, Röshammar D, Beetz N.

The Population PKPD of Unacylated and Acylated Ghrelin Following Single Rising Doses of BI 1356225 in Healthy Subjects is Impacted by the Time Since Last Meal

Pharmetheus Affiliates

Sahota T, Bergstrand M, Milligan P, Zamuner S, Chen C, Fairman D.

Towards Industrialisation of Probability of Pharmacological Success (PoPS)

Pharmetheus Affiliates

Eckernäs E, Timmermann C, Röshammar D, Ashton M.

Population Pharmacokinetic/Pharmacodynamic Modelling of the Psychedelic Experience Induced by N,N-dimethyltryptamine

Pharmetheus Affiliates

Kanacher T, Michon I, Lindauer A, Mezzalana E, Dansirikul C, Veau C, Mantilla JDG, Nock V, Fleury A.

A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug–Drug–Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol and Caffeine

Pharmetheus Affiliates

Valenzuela B, Pérez-Ruixo JJ, Leirens Q, Ouwerkerk-Mahadevan S, Poggesi I.

Effect of Ponesimod Exposure on Total Lymphocyte Dynamics in Patients with Multiple Sclerosis

Pharmetheus Affiliates

Schmid U, Weber B, Sarr C, Freiwald M.

Exposure–Safety Analyses of Nintedanib in Patients with Chronic Fibrosing Interstitial Lung Disease

Pharmetheus Affiliates

Röshammar D, Huang F, Albisetti M, Bomgaars L, Chalmers E, Luciani M, Halton J, Mitchell LG, Bergstrand M, Ibrahim MMA, Joseph D, Tartakovsky I, Gropper S, Brueckmann M, Brandão LR.

Pharmacokinetic Modeling and Simulation Support for Age‐ and Weight‐Adjusted Dosing of Dabigatran Etexilate in Children with Venous Thromboembolism

Pharmetheus Affiliates

Smania G, Jonsson EN.

Conditional Distribution Modeling as an Alternative Method for Covariates Simulation: Comparison with Joint Multivariate Normal and Bootstrap Techniques

Pharmetheus Affiliates

Schmid U, Weber B, Magnusson MO, Freiwald M.

Exposure-Efficacy Analyses of Nintedanib in Patients with Chronic Fibrosing Interstitial Lung Disease

Pharmetheus Affiliates

Ljungberg A, Segelsjö M, Dahlman P, Helenius M, Magnusson MO, Magnusson A.

Comparison of Quality of Urinary Bladder Filling in CT Urography with Different Doses of Furosemide in the Work-Up of Patients with Macroscopic Hematuria

Pharmetheus Affiliates

Sjögren E, Tarning J, Barnes KI, Jonsson EN.

A Physiologically-Based Pharmacokinetic Framework for Prediction of Drug Exposure in Malnourished Children

Pharmetheus Affiliates

2020

Kanacher T, Lindauer A, Mezzalana E, Michon I, Veau C, Mantilla JD, Nock V, Ivaturi V.

A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug-Drug-Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine

Pharmetheus Affiliates

Anziano RJ, Milligan P.

Model Informed Drug Development: Collaboration Through A Common Framework

Pharmetheus Affiliates

Svensson RJ, Ribbing J, Kotani N, Dolton M, Vadhavkar S, Cheung D, Staton T, Choy DF, Putnam W, Jin J, Budha N, Karlsson MO, Quartino A, Zhu R.

Population RTTE Analysis of Exacerbations in Asthma Patients: a Novel Approach for Predicting Asthma Exacerbations Based on Biomarkers, Spirometry and Diaries/Questionnaires

Pharmetheus Affiliates

Langenhorst JB, Boss J, van Kesteren C, Lalmohamed A, Kuball J, Egberts ACG, Boelens JJ, Huitema ADR, van Maarseveen EM.

A Semi-Mechanistic Model Based on Glutathione Depletion to Describe Intra-Individual Reduction in Busulfan Clearance

Pharmetheus Affiliates

Roeshammar D, Huang F, Albisetti M, Bomgaars L, Chalmers E, Luciani M, Halton J, Mitchell L, Joseph D, Tartakovsky I, Gropper S, Reilly P, Brueckmann M, Brandão L, on Behalf of the Study Investigators.

Pharmacokinetic Modelling and Simulation Support the Age and Body-Weight-Adjusted Dosing of Dabigatran Etexilate in Paediatric Patients with Venous Thromboembolism, PB1271

Pharmetheus Affiliates

Langenhorst JB, Dorlo TPC, van Kesteren C, van Maarseveen E, Nierkens S, de Witte MA, Boelens JJ, Huitema ADR.

Clinical Trial Simulation To Optimize Trial Design for Fludarabine Dosing Strategies in Allogeneic Hematopoietic Cell Transplantation

Pharmetheus Affiliates

Mitra A, Suarez-Sharp S, Pepin XJH, Flanagan T, Zhao Y, Kotzagiorgis E, Parrott N, Sharan S, Tistaert C, Heimbach T, Zolnik B, Sjögren E, Wu F, Anand O, Kakar S, Li M, Veerasingham S, Kijima S, Lima Santos GM, Ning B, Raines K, Rullo G, Mandula H, Delvadia P, Dressman J, Dickinson PA, Babiskin A.

Applications of Physiologically Based Biopharmaceutics Modeling (PBBM) to Support Drug Product Quality: A Workshop Summary Report

Pharmetheus Affiliates

Pepin X, Dressman J, Parrott N, Delvadia P, Mitra A, Zhang X, Babiskin A, Kolhatkar V, Seo P, Taylor L, Sjögren E, Butler J, Kostewicz E, Tannergren C, Koziolek M, Kesisoglou F, Dallmann A, Zhao Y, Suarez-Sharp S.

In Vitro Biopredictive Methods: A Workshop Summary Report

Pharmetheus Affiliates

2019

Lippert J, Burghaus R, Edginton A, Frechen S, Karlsson M, Kovar A, Lehr T, Milligan P, Nock V, Ramusovic S, Riggs M, Schaller S, Schlender J, Schmidt S, Sevestre M, Sjögren E, Solodenko J, Staab A, Teutonico D.

Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Pharmetheus Affiliates

Schoemaker R, Nayak S, Harnisch LO, Karlsson MO, on behalf of VISTA-ICH Collaboration.

Modeling and Simulation of the Modified Rankin Scale and National Institutes of Health Stroke Scale Neurological Endpoints in Intracerebral Hemorrhage

Pharmetheus Affiliates

Heimbach T, Suarez-Sharp S, Kakhi M, Holmstock N, Olivares-Morales A, Pepin X, Sjögren E, Tsakalozou E, Seo P, Li M, Zhang X, Lin HP, Montague T, Mitra A, Morris D, Patel N, Kesisoglou F.

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link-a Workshop Summary Report

Pharmetheus Affiliates

Brekkan A, Lopez-Lazaro L, Plan EL, Nyberg J, Kankanwadi S, Karlsson MO.

Sensitivity of Pegfilgrastim Pharmacokinetic and Pharmacodynamic Parameters to Product Differences in Similarity Studies

Pharmetheus Affiliates

Nyberg J, Jonsson EN, Karlsson MO, Häggström J, members of the HBGDki Community.

Properties of the Full Random Effect Modelling Approach With Missing Covariates

Pharmetheus Affiliates

Sargentini L, Hansson E, Bergstrand M, Callewaert F, Sousa RP.

Effect of Plasma Exchange on the Pharmacokinetics and Pharmacodynamics of Caplacizumab, PS1487

Pharmetheus Affiliates

Sargentini L, Hansson E, Bergstrand M, Callewaert F, Sousa RP.

Caplacizumab Model-Based Dosing Recommendations in Pediatric Patients with Acquired Thrombotic Thrombocytopenic Purpura, PB2249

Pharmetheus Affiliates

Bergstrand M, Hansson E, Sargentini-Maier ML.

Caplacizumab Dosing Rational in aTTP Patients Supported by Mechanism Based PKPD Modelling

Pharmetheus Affiliates

Kristoffersson A, Röshammar D, Plan EL.

Assessment of Expected Drug Exposure Relative Maximum Safety Limits in Early Phase Studies

Pharmetheus Affiliates

Brekkan A, Lopez-Lazaro L, Plan EL, Acharya C, Yngman G, Nyberg J, Hooker AC, Kankanwadi S, Karlsson MO.

Model Based Support to Biosimilarity Assessment Planning – A Case Study of Pegfilgrastim

Pharmetheus Affiliates

Nyberg J, Karlsson MO, Jonsson EN.

Implicit and Efficient Handling of Missing Covariate Information Using Full Random Effects Modelling

Pharmetheus Affiliates

Sjögren E, Jonsson EN.

A PBPK Framework to Predict Drug Exposure in Malnourished Children

Pharmetheus Affiliates

Sarr C, Magnusson MO, Vajjah P, Zamacona M.

Population PK and PASI Exposure-Response Modelling for Certolizumab Pegol in Patients with Chronic Plaque Psoriasis

Pharmetheus Affiliates

Mats Magnusson

Mats Magnusson, Ph.D.

Ibrahim MMA, de Mello VD, Uusitupa M, Tuomilehto J, Lindström J, Kjellsson MC, Karlsson MO.

Competing Risks Analysis of the Finnish Diabetes Prevention Study

Pharmetheus Affiliates

Netterberg I, Li CC, Molinero L, Budha N, Sukumaran S, Stroh M, Jonsson EN, Friberg LE.

A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab-Treated non-small Cell Lung Cancer Patients

Pharmetheus Affiliates

2018

Guiastrennec B, Sonne DP, Bergstrand M, Vilsbøll T, Knop FK, Karlsson MO.

Model-Based Prediction of Plasma Concentration and Enterohepatic Circulation of Total Bile Acids in Humans

Pharmetheus Affiliates

Terranova N, Smith MK, Nordgren R, Comets E, Lavielle M, Harling K, Hooker AC, Sarr C, Mentré F, Yvon F, Swat MJ.

The Standard Output: A Tool-Agnostic Modeling Storage Format

Pharmetheus Affiliates

Suarez-Sharp S, Cohen M, Kesisoglou F, Abend A, Marroum P, Delvadia P, Kotzagiorgis E, Li M, Nordmark A, Bandi N, Sjögren E, Babiskin A, Heimbach T, Kijima S, Mandula H, Raines K, Seo P, Zhang X.

Applications of Clinically Relevant Dissolution Testing: Workshop Summary Report

Pharmetheus Affiliates

Brekkan A, Lopez-Lazaro L, Yngman G, Plan EL, Acharya C, Hooker AC, Kankanwadi S, Karlsson MO.

A Population Pharmacokinetic-Pharmacodynamic Model of Pegfilgrastim

Pharmetheus Affiliates

Jonsson EN, Harling K.

Increasing the Efficiency of the Covariate Search Algorithm in the SCM

Pharmetheus Affiliates

Kantasiripitak W, Sjögren E, Magnusson MO.

Bridging Physiologically Based Pharmacokinetic (PBPK) and Population Pharmacokinetic (PopPK) Analyses in Paediatric Drug Development: A Case Study Based on Intravenous Esomeprazole

Pharmetheus Affiliates

Kloprogge F, Workman L, Borrman S, Tékété M, Lefèvre G, Hamed K, Piola P, Ursing J, Kofoed PE, Mårtensson A, Ngasala B, Björkman A, Ashton M, Friberg Hietala S, Francesca A, Parikh S, Mwai L, Davis TME, Karunajeewa HA, Salman S, Checchi F, Fogg C, Newton PN, Mayxay M, Deloron P, Faucher JF, Nosten F, Ashley EA, McGready R, van Vugt M, Proux P, Price RN, Karbwang J.

Artemether-Lumefantrine Dosing for Malaria Treatment in Young Children and Pregnant Women: A Pharmacokinetic-Pharmacodynamic Meta-Analysis

Pharmetheus Affiliates

Rasmussen CH, Smith MK, Ito K, Sundararajan V, Magnusson MO, Jonsson NE, Fostvedt L, Burger P, McFadyen L, Tensfeldt TG, Nicholas T.

PharmTeX: a LaTeX-Based Open-Source Platform for Automated Reporting Workflow

Pharmetheus Affiliates

Mats Magnusson

Mats Magnusson, Ph.D.

2017

Dosne AG, Bergstrand M, Karlsson MO.

An Automated Sampling Importance Resampling Procedure for Estimating Parameter Uncertainty

Pharmetheus Affiliates

Conrado DJ, Karlsson MO, Romero K, Sarr C, Wilkins JJ.

Open Innovation: Towards Sharing of Data, Models and Workflows

Pharmetheus Affiliates

Friberg Hietala S, Manolis E, Musuamba FT.

A Regulatory View on Dose Finding Studies and on the Value of Dose-Exposure-Response Analysis

In O’Quigley J, Iasonos A, Bornkamp B, (Eds), Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials. Boca Raton FL:CRC Press.

Pharmetheus Affiliates

Yngman G, Nyberg J, Jonsson EN, Karlsson MO.

Practical Considerations for Using the Full Random Effects Modeling (FREM) Approach to Covariate Modeling

Pharmetheus Affiliates

Hamrén B, Röshammar D, Nyberg J, Bergstrand M, Andersson T, Storey RF, Stanski D.

Pharmacokinetic and Exposure-Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients with Prior Myocardial Infarction (PEGASUS-TIMI 54)

Pharmetheus Affiliates

Röshammar D, Nyberg J, Andersson T, Stanski D, Storey RF, Hamrén B.

Exposure-Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients With Prior Myocardial Infarction

Pharmetheus Affiliates

Röshammar D, Bergstrand M, Andersson T, Storey RF, Hamrén B.

Population Pharmacokinetics of Ticagrelor and AR-C124910XX in Patients with Prior Myocardial Infarction

Pharmetheus Affiliates

Magnusson MO, Samtani MN, Plan EL, Jonsson EN, Rossenu S, Vermeulen A, Russu A.

Dosing and Switching Strategies for Paliperidone Palmitate 3-Month Formulation in Patients with Schizophrenia Based on Population Pharmacokinetic Modeling and Simulation, and Clinical Trial Data

Pharmetheus Affiliates

Magnusson MO, Samtani MN, Plan EL, Jonsson EN, Rossenu S, Vermeulen A, Russu A.

Population Pharmacokinetics of a Novel Once-Every 3 Months Intramuscular Formulation of Paliperidone Palmitate in Patients with Schizophrenia

Pharmetheus Affiliates

Nguyen THT, Mouksassi M-S, Holford N, Al-Huniti N, Freedman I, Hooker AC, John J, Karlsson MO, Mould DR, Pérez-Ruixo JJ, Plan EL, Savic R, van Hasselt JGC, Weber B, Zhou C, Comets E, Mentré F, for the Model Evaluation Group of the International Society of Pharmacometrics (ISoP) Best Practice Committee.

Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics

Pharmetheus Affiliates

Dosne AG, Bergstrand M, Karlsson MO.

An Automated Sampling Importance Resampling Procedure for Estimating Parameter Uncertainty

Pharmetheus Affiliates

2016

Slejko JF, Willke RJ, Ribbing J, Milligan P.

Translating Pharmacometrics to a Pharmacoeconomic Model of COPD

Pharmetheus Affiliates

Magnusson MO.

Application of a Multi-Criteria Decision Analysis Model in the Dose Selection of Combination Therapy for Overactive Bladder

Pharmetheus Affiliates

Mats Magnusson

Mats Magnusson, Ph.D.

Jonsson EN, Nyberg J, Häggström J, Lifecycle Auxology & Neurocognitive Development team, representing the Healthy Birth, Growth and Development knowledge integration (HBGDki) community.

Determinants for Physical Growth Patterns in Low- and Middle-Income Countries

Pharmetheus Affiliates

Magnusson MO, Plan EL, Remy A, König M, Aigner S, Braun V, Zipp D, Zhou X, Wolter R, Schüttrumpf J, Wartenberg-Demand A, Dälken B, Rharbaoui F.

Population PKPD Analysis of CD4 and ACR Response after SC Administration of Tregalizumab to Patients with Rheumatoid Arthritis

Pharmetheus Affiliates

Mats Magnusson

Mats Magnusson, Ph.D.

Magnusson MO, Jonsson EN.

Reproducible Reporting

Pharmetheus Affiliates

Mats Magnusson

Mats Magnusson, Ph.D.

Mazzei P, Mezzalana E, Smania G, Jonsson EN, Jönsson S, Bouchene S, Karlsson MO, Scartoni S, Capriati A.

Population Exposure-Response Modeling of Oral Nepadutant Administration in Infants with Colic

Pharmetheus Affiliates

Schoemaker R, Nayak S, Denney WS, Jonsson EN, Karlsson MO, Harnisch LO, on behalf of the VISTA-ICH Collaborators.

Modelling and Simulation of Neurological Endpoints (Modified Rankin Scale [mRS] and National Institute of Health Stroke Scale [NIHSS]) to Aid Clinical Trial Design in Intracerebral Hemorrhage (ICH)

Pharmetheus Affiliates

Ribbing J, Korell J, Cerasoli F, Milligan P, Martin SW, Karlsson MO.

Predicting Reductions in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations from FEV1 – A Model-Based Meta-Analysis of Literature Data from Controlled Randomized Clinical Trials

Pharmetheus Affiliates

Van Schaick E, Benninga MA, Levine A, Magnusson MO, Troy S.

Development of a Population Pharmacokinetic Model of Prucalopride in Children with Functional Constipation

Pharmetheus Affiliates

Mats Magnusson

Mats Magnusson, Ph.D.

Jonsson EN, Xie R, Marshall SF, Arends RH.

Population Pharmacokinetics of Tanezumab in Phase 3 Clinical Trials for Osteoarthritis Pain

Pharmetheus Affiliates

Korell J, Martin SW, Karlsson MO, Ribbing J.

A Model-Based Longitudinal Meta-Analysis of FEV1 in Randomized COPD Trials

Pharmetheus Affiliates

2015

Norberg Å, Pauline Koch, Kanes SJ, Björnsson MA, Barassin S, Ahlén K, Kalman S.

A Bolus and Bolus Followed by Infusion Study of AZD3043, an Investigational Intravenous Drug for Sedation and Anesthesia: Safety and Pharmacodynamics in Healthy Male and Female Volunteers

Pharmetheus Affiliates

Khariton T, Jonsson EN, Bergstrand M, Carrothers TJ, Ghahramani P.

Population Pharmacokinetic (PPK) Modeling of Vilazodone in Adolescent Patients with Major Depressive Disorder (MDD)

Pharmetheus Affiliates

Khariton T, Jonsson EN, Bergstrand M, Carrothers TJ, Ghahramani P.

PKPD Modeling of Vilazodone (VLZ) in Adult Patients with Generalized Anxiety Disorder (GAD)

Pharmetheus Affiliates

Magnusson MO, Samtani MN, Plan EL, Jonsson EN, Rossenu S, Vermeulen A.

Population Pharmacokinetic Simulations of Two Paliperidone Palmitate Formulations

Pharmetheus Affiliates

Magnusson MO, Samtani MN, Plan EL, Jonsson EN, Rossenu S, Vermeulen A.

Population Pharmacokinetic Modeling of Paliperidone Palmitate 3-Month Formulation

Pharmetheus Affiliates

Visser SAG, Fancourt C, Valiathan C, Carballo-Jane E, Van Heek M, Bergstrand M, Karlsson MO, Kjellsson MC, Cho CR.

Translational Modelling of Regular Human Insulin Pharmacokinetics and Glucose Dynamics in Minipig and Dog

Pharmetheus Affiliates

Buatois S, Retout S, Gieschke R, Ueckert S, Frey N.

Using Item Response Theory to Yield Information from the MDS-UPDRS Items in Parkinson’s Disease Clinical Trials

Pharmetheus Affiliates

Bosch R, Gao W, Vargo R, Valiathan C, Fancourt C, Kothare PA, Kjellsson MC, Karlsson MO.

Application of a Semi-Mechanistic, Integrated Glucose-Insulin Model to Graded Glucose Infusion Placebo Data to translate Glucose Insulin dynamics between Healthy Humans and Non-Human Primates

Pharmetheus Affiliates

Hamberg AK, Hellman J, Dahlberg J, Jonsson EN, Wadelius M.

A Bayesian Decision Support Tool for Efficient Dose Individualization of Warfarin in Adults and Children

Pharmetheus Affiliates

2014

Helenius M, Dahlman P, Magnusson MO, Lönnemark M, Magnusson A.

Contrast Enhancement in Bladder Tumors Examined with CT Urography Using Traditional Scan Phases

Pharmetheus Affiliates

Mats Magnusson

Mats Magnusson, Ph.D.

Khariton T, Bergstrand M, Plan EL, Ghahramani P.

A Population PKPD Model for Changes in Sexual Function Questionnaire (CSFQ) in Patients with Major Depressive Disorder (MDD) Treated with Vilazodone or Placebo

Pharmetheus Affiliates